… that reduced expression of Grhl3 causes spina bifida, we reasoned that reinstatement of
Grhl3 expression in ct/ct embryos should prevent the occurrence of spina bifida. Therefore, we …

… expression. Our study population, consisting of 121 mothers of a spina bifida affected child,
109 spina bifida … 3/6 genotype on spina bifida risk, we expected an increased risk of having a …

… It is generally accepted that inadequate intake of natural folate, or its synthetic form, folic acid,
before and during early pregnancy, is associated with an increased risk of spina bifida and …

… Growth factor expression was dysregulated in spinal cords with spina bifida. After MSC
transplantation, we observed significantly increased expression of EGF, fibroblast growth factor (…

… mutation which leads to increased expression of Grhl2. Knock-in of Grhl2 into the Grhl3
locus has recently been found to generate embryos with spina bifida which resemble Grhl3 null …

… associated with increased risk of spina bifida are increased pregnancy weight [153… expressed
in the surface ectoderm adjacent to the open spinal neural tube, while BMP4 is expressed …

… of miR-451, miR-375 and p53 increased in spina bifida rat fetuses. … in the expression of
14-3-3ζ in spina bifida rat fetuses between E12 and E15. Low 14-3-3ζ expression levels were …

… In this study, we detected increased LC3 expression both in the dorsal murine … in LC3
expression in NTD cases compared with healthy controls. LC3 expression is strongly expressed in …

… , was significantly positively associated with an increased risk of spina bifida, we propose
that folate deprivation-related hypermethylation of the gli2 promoter is a potential risk factor of …

… with spinal cord involvement. The most clinically significant subtype is myelomeningocele
(open spina bifida), which is a condition characterized by failure of the lumbosacral spinal …