Epidural stimulation of the spinal cord in spinal cord injury: current status and future challenges

VR Edgerton, S Harkema - Expert review of neurotherapeutics, 2011 - Taylor & Francis
… and to step using epidural stimulation as demonstrated successfully in the … spinal circuitry?
We made a series of observations demonstrating the feasibility of using epidural stimulation

Stepping-like movements in humans with complete spinal cord injury induced by epidural stimulation of the lumbar cord: electromyographic study of compound …

K Minassian, B Jilge, F Rattay, MM Pinter, H Binder… - Spinal cord, 2004 - nature.com
… activity evoked by epidural lumbar cord stimulation as described in … stimulation were routed
through monosynaptic pathways. Sustained stimulation at 5–50 Hz engaged central spinal

[HTML][HTML] Targeting lumbar spinal neural circuitry by epidural stimulation to restore motor function after spinal cord injury

K Minassian, WB McKay, H Binder, US Hofstoetter - Neurotherapeutics, 2016 - Elsevier
Epidural spinal cord stimulation has a long history of application for improving motor control
in spinal cord injury. … Early work revealed that the spinal circuitry involved in lower-limb motor …

Lumbosacral spinal cord epidural stimulation improves voiding function after human spinal cord injury

AN Herrity, CS Williams, CA Angeli, SJ Harkema… - Scientific reports, 2018 - nature.com
… Deficits in urologic function after spinal cord injury (SCI) … investigate the efficacy of spinal
cord epidural stimulation (scES) … Varying combinations of stimulating cathode electrodes were …

Association of epidural stimulation with cardiovascular function in an individual with spinal cord injury

CR West, AA Phillips, JW Squair, AM Williams… - JAMA …, 2018 - jamanetwork.com
… motor-complete cervical SCI. We postulate that epidural stimulation can specifically modulate
… potential of sympathetic circuitry via the stimulation of dorsal afferent relays (Figure 2). …

[HTML][HTML] Epidural electrical stimulation for spinal cord injury

EH Choi, S Gattas, NJ Brown, JD Hong… - Neural Regeneration …, 2021 - journals.lww.com
spinal cord injury. We also discuss and summarize the animal and human studies that
evaluated epidural electrical stimulation in spinal cord injury. … Studies of epidural stimulation in …

Epidural spinal cord stimulation as an intervention for motor recovery after motor complete spinal cord injury

JT Hachmann, A Yousak, JJ Wallner… - Journal of …, 2021 - journals.physiology.org
Spinal cord injury (SCI) commonly results in permanent loss … have shown that epidural spinal
cord stimulation may provide … advances of lumbosacral epidural stimulation for restoration …

Normalization of blood pressure with spinal cord epidural stimulation after severe spinal cord injury

SJ Harkema, S Wang, CA Angeli, Y Chen… - Frontiers in human …, 2018 - frontiersin.org
… issues after severe spinal cord injury (SCI), affecting health, rehabilitation, and quality of
life. We previously reported that targeted lumbosacral spinal cord epidural stimulation (scES) …

Epidural spinal-cord stimulation facilitates recovery of functional walking following incomplete spinal-cord injury

MR Carhart, J He, R Herman… - … on neural systems …, 2004 - ieeexplore.ieee.org
… -dependent individuals with chronic, incomplete spinal-cord injury. By coordinating epidural
stimulation of the dorsal structures of the spinal cord with partial weight bearing treadmill …

Epidural electrical stimulation: a review of plasticity mechanisms that are hypothesized to underlie enhanced recovery from spinal cord injury with stimulation

JT Eisdorfer, RD Smit, KM Keefe, MA Lemay… - Frontiers in Molecular …, 2020 - frontiersin.org
stimulation is applied epidurally to the dorsal aspect of the lumbar spinal cord. In 1976,
epidural stimulation was introduced to alleviate spasticity in Multiple Sclerosis. Since then, …