Exploration of TRPV1 Splice Variant Expression in Rat Dorsal Root Ganglia Following Sciatic Nerve Injury

KA Andersen - 2010 - dsc.duq.edu
… of splice variants of TRPV1 in pain pathways is not well known. In this study, the mRNA
expression of TRPV1 and 3 splice variants (… is perhaps best known as the capsaicin receptor. …

[HTML][HTML] Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity

Y Zhou, Y Suzuki, K Uchida, M Tominaga - Nature communications, 2013 - nature.com
… neurons and functions as a nociceptive receptor 3,21 . Starting … fragment was an alternative
splice variant. To confirm that … corresponded to a Trpa1 splice variant whose sequence was …

Agonist-dependence of functional properties for common nonsynonymous variants of human transient receptor potential vanilloid 1

S Wang, J Joseph, L Diatchenko, JY Ro, MK Chung - Pain, 2016 - journals.lww.com
… of alternative splicing To estimate relative abundance of alternative splicing variants of human
TRPV1, … In this analysis, maximal capsaicin-evoked current density of each variant was not …

(604): Involvement of proteinase-activated receptors on nociceptive behavioral responses of rats following intradermal injection of capsaicin

X Zhang, Y Lei, L Fang, W Willis - The Journal of Pain, 2006 - jpain.org
… Additionally, our search reveals two splicing variants (GI38146390, AY364890 and … a
morphine-6-glucoronide (M6G) receptor. M6G analgesia is sensitive to antisense probes against …

[HTML][HTML] Cell-specific alternative splicing increases calcium channel current density in the pain pathway

TJ Bell, C Thaler, AJ Castiglioni, TD Helton… - Neuron, 2004 - cell.com
capsaicin responsiveness, and biophysical analysis at the single-cell level to identify a novel
splice … exerts its effects via activation of the vanilloid receptor (VR1). Consistent with this, we …

TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells

MH Vos, TR Neelands, HA McDonald… - Journal of …, 2006 - Wiley Online Library
… Transient receptor potential channel type V (TRPV) 1 is a non… In this study, we cloned human
TRPV1 splice variant TRPV1b … is a non-functional splice variant of TRPV1. The recombinant …

[HTML][HTML] Diversity effect of capsaicin on different types of skeletal muscle

G Zhou, L Wang, Y Xu, K Yang, L Luo, L Wang… - Molecular and cellular …, 2018 - Springer
capsaicin to MyHCs and capsaicin receptors in the gastrocnemius and soleus. a Western blot
analysis of TRPV1, CB1, and CB2 receptors … presence of different splice variants of TRPV1 …

[HTML][HTML] A single TRPV1 amino acid controls species sensitivity to capsaicin

Y Chu, BE Cohen, H Chuang - Scientific reports, 2020 - nature.com
… Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proceedings
of the National Academy of Sciences of the United States of America 97, 8134–8139, https:…

Capsaicin receptors as target molecules on nociceptors for development of novel analgesic agents

J Szolcsányi - Molecular pathomechanisms and new trends in …, 2002 - taylorfrancis.com
… red as capsaicin receptorcapsaicin and resiniferatoxin on the capsaicin receptor.
Capsazepine is the first commercially available competitive capsaicin antagonist at the VR1 receptor

Functional characterisation of the S512Y mutant vanilloid human TRPV1 receptor

KG Sutton, EM Garrett, AR Rutter… - British journal of …, 2005 - Wiley Online Library
… residues highlighted to participate in mediating capsaicin- and proton-dependent activation
did not affect heat. In addition, a novel human TRPV1 splice variant has been found (named …