Distinct properties of Ca2+–calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel

SY Lau, E Procko, R Gaudet - Journal of General Physiology, 2012 - rupress.org
receptor belonging to the TRP superfamily of nonselective cation channels. As a polymodal
receptor, … but plays only a minor role in the capsaicin-induced desensitization we measured. …

Capsaicin causes inactivation and degradation of the androgen receptor by inducing the restoration of miR-449a in prostate cancer

L Zheng, J Chen, Z Ma, W Liu, F Yang… - Oncology …, 2015 - spandidos-publications.com
… of the androgen receptor (AR) by capsaicin and further … We discovered that capsaicin
prevented tumor proliferation … of miR-449a induced by capsaicin treatment resulted in the …

Tachykinins amplify the action of capsaicin on central histaminergic neurons

OA Sergeeva, K Mazur, A Kernder, HL Haas… - Peptides, 2022 - Elsevier
… (PNS) nociception capsaicin-receptor signalling is amplified … encodes several other splice
variants known as neurokinin A, … of SP is the highest among multiple splice variants [19]. SP is …

Agonist recognition sites in the cytosolic tails of vanilloid receptor 1

J Jung, SY Lee, SW Hwang, H Cho, J Shin… - Journal of Biological …, 2002 - ASBMB
… Moreover, unlike other ligand-gated channels that produce fast synaptic transmission,
vanilloids are known to act on the capsaicin receptor from the intracellular side ( …

Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors

CA Reilly, JL Taylor, DL Lanza, BA Carr… - Toxicological …, 2003 - academic.oup.com
… Molecular cloning of an N-terminal splice variant of the capsaicin receptor. Loss of N-terminal
domain suggests functional divergence among capsaicin receptor subtypes. …

Functional role of C-terminal cytoplasmic tail of rat vanilloid receptor 1

V Vlachová, J Teisinger, K Sušánková… - Journal of …, 2003 - Soc Neuroscience
… This channel can be activated by hypertonic solutions; however, it is insensitive to capsaicin.
Another TRPV1 variant, the VR 5′ splice variant, which is also insensitive to vanilloids, low …

(101) Functional characterization of the novel alternatively spliced form of mu-opioid receptor OPRM1

P Gris, P Cheng, J Gauthier, S Shabalina, W Maixner… - The Journal of …, 2008 - jpain.org
… of human alternative splice variants containing novel exon 13 … We hereby report that the
splice variant containing exon 13 … underlying virus escape from capsaicin-induced activation of …

A review of TRP channels splicing

E Vázquez, MA Valverde - Seminars in cell & developmental biology, 2006 - Elsevier
… In some cases the splicing variant shows stronger activation, as for TRPC4β in response to
… long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant

Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system

BR Bianchi, CH Lee, MF Jarvis, R El Kouhen… - European journal of …, 2006 - Elsevier
… One of the aims of the present study was to determine whether activation of the recombinant
hTRPV1 receptor by exogenous agonists (resiniferatoxin, capsaicin, tinyatoxin, olvanil, …

An overview of the actions of capsaicin and its receptor, TRPV1, and their relations to small primary sensory neurons

A Hiura, H Nakagawa - Anti-Inflammatory & Anti-Allergy Agents …, 2011 - ingentaconnect.com
… Agonist (resiniferatoxin) and antagonists (capsazepine and ruthenium red) of capsaicin are
… discovery of capsaicin receptor, TRPV1, and its characteristic features (polymodal receptor) …