Carboxyl-terminal domain of transient receptor potential vanilloid 1 contains distinct segments differentially involved in capsaicin-and heat-induced desensitization

J Joseph, S Wang, J Lee, JY Ro, MK Chung - Journal of Biological …, 2013 - ASBMB
… in activation by capsaicin and heat and that capsaicin and heat desensitize TRPV1 through
apparently distinct mechanisms, we hypothesized that capsaicin and heat desensitize …

Complex regulation of TRPV1 by vanilloids

A Szallasi, PM Blumberg - TRP ion channel function in sensory …, 2007 - books.google.com
… , EA, and Bunnett, NW Protease activated receptor 2 sensitizes the capsaicin receptor transient
receptor VR1 and VR1 5’splice variant RNA expression in rat. Neurosci. 107: 373, 2001. …

(608): Quantitative analysis of sodium channel expression in normal and painful human teeth

R Rzasa, M Henry, L Johnson, S Levinson - The Journal of Pain, 2006 - jpain.org
… domain is exposed and the cleaved receptors are activated. It is known … of capsaicin. This
suggests that PAR1 may be involved in … Additionally, our search reveals two splicing variants (…

Capsaicin indirectly regulates TRPA1 via the arachidonic acid cascade, resulting in TJ opening

Y Kanda, M Mukaiyama, Y Yamasaki… - Bioscience …, 2024 - academic.oup.com
Capsaicin is thought to cause a series of biological effects by acting on the capsaicin receptor
… In MDCK II monolayers, PTGS1, which encodes COX1 and its splice variant COX3, were …

The potential antitumor effects of capsaicin

I Díaz-Laviada, N Rodríguez-Henche - Capsaicin as a therapeutic …, 2014 - Springer
… However, the capsaicin-induced apoptotic effect at high doses is a receptor-independent
mechanism, as … The involvement of PPAR receptors in the capsaicin antitumor activity has been …

Transient receptor potential channels in pain and inflammation: therapeutic opportunities

MA Schumacher - Pain Practice, 2010 - Wiley Online Library
… , the capsaicin receptor, also known as transient receptor potential … splice variant subunit.
Although there is a reduction of keratinocyte and fibroblast growth in the presence of capsaicin (…

SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population

O Carreno, R Corominas… - American Journal of …, 2012 - Wiley Online Library
… TRPV1 was identified as the capsaicin receptor and is activated by noxious temperature, …
splicing enhancers or silencers, changing of splicing pattern or efficiency by disrupting splice

Future perspectives of capsaicin research

J Szolcsányi - Capsicum, 2003 - taylorfrancis.com
… The capsaicin receptor-encoding cDNA was identified by … other factors, including splice
variants, aggregation with other … varying responsiveness of the capsaicin receptor/ ion channel …

Expression of vanilloid VR1 receptor in PC12 cells

A Someya, K Kunieda, N Akiyama… - Neurochemistry …, 2004 - Elsevier
receptor subtype 1 (VR1), which is a nonselective cation channel with high Ca 2+ permeability.
Although VR1 and its splice variant … Axonal transport of VR1 capsaicin receptor mRNA in …

Capsaicin sensitizes malignant glioma cells to TRAIL-mediated apoptosis via DR5 upregulation and survivin downregulation

JY Kim, EH Kim, SU Kim, TK Kwon, KS Choi - Carcinogenesis, 2010 - academic.oup.com
… Here, we show that subtoxic doses of capsaicin effectively … cells, cotreatment with capsaicin
and TRAIL efficiently restored … with capsaicin significantly upregulated DR5, a death receptor