Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation and process attributes

JT Pinto, E Faulhammer, J Dieplinger, M Dekner… - Drying …, 2021 - Taylor & Francis
… and discuss the spray-drying of diverse protein pharmaceuticals and … Further, key quality
aspects of spray-dried protein solids are … into the future of protein pharmaceuticals spray-drying. …

The spray drying of pharmaceuticals

J Broadhead, SK Edmond Rouan… - Drug development and …, 1992 - Taylor & Francis
… to pharmaceuticals. In this article the applications of spray drying in the pharmaceutical industry
… , such as the the production of granulations by spray drying, as well as some more novel …

Feasibility study on spray-drying protein pharmaceuticals: recombinant human growth hormone and tissue-type plasminogen activator

M Mumenthaler, CC Hsu, R Pearlman - Pharmaceutical research, 1994 - Springer
… In pharmaceutical formulation research, when a protein is … for preparing dry protein
pharmaceuticals is lyophilization. … of a thermal effect on the protein than other drying methods. The …

Spray drying technique: II. Current applications in pharmaceutical technology

K Sollohub, K Cal - Journal of pharmaceutical sciences, 2010 - Elsevier
… of spray drying in pharmaceutical technology. The topics discussed include the obtention of
excipients and cospray driedspray-dried particles. This review also describes the use of the …

Pharmaceutical Particle Engineering via Spray Drying

R Vehring - Pharmaceutical research, 2008 - Springer
… This review focuses exclusively on spray drying (29–35), with an emphasis on the literature
… processes and alternative drying processes such as spray freeze drying, or supercritical fluid …

Pharmaceutical protein solids: Drying technology, solid-state characterization and stability

Y Chen, TT Mutukuri, NE Wilson, QT Zhou - Advanced drug delivery …, 2021 - Elsevier
… Technologies such as spray drying and spray freeze drying are … drying temperature in
spray drying may induce protein denaturation. The stresses affecting the stability of protein

The challenge of drying method selection for protein pharmaceuticals: product quality implications

AM Abdul‐Fattah, DS Kalonia, MJ Pikal - Journal of pharmaceutical …, 2007 - Elsevier
Spray drying and freeze drying are by far the two most popular … of drying protein solutions
in the pharmaceutical industry. Supercritical fluid technology, spray freeze drying (SFD), spray

Spray drying of biopharmaceuticals: stability and process considerations

M Ameri, YF Maa - Drying technology, 2006 - Taylor & Francis
… drugs as spray drying was performed primarily on co-current spray dryer in a single-stage
mode. In this review we discuss the respective dehydration mechanisms of spray drying and …

Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches

A Ziaee, AB Albadarin, L Padrela, T Femmer… - … of Pharmaceutical …, 2019 - Elsevier
… of spray drying process, current technology and various components used in spray drying
… critical formulation and processing factors in spray drying of small molecule drugs and large …

Engineering advances in spray drying for pharmaceuticals

JM Baumann, MS Adam, JD Wood - Annual review of chemical …, 2021 - annualreviews.org
Spray drying is a versatile technology that has been applied widely in the chemical, food,
and, most recently, pharmaceutical … applications of spray drying for pharmaceuticals. An in-…