Mutation signature analysis identifies increased mutation caused by tobacco smoke associated DNA adducts in larynx squamous cell carcinoma compared with oral …

AP South, NY den Breems, T Richa, U Nwagu… - Scientific reports, 2019 - nature.com
… We identify that mutations linked to DNA adducts associated with tobacco smoke exposure
are … growth and increased susceptibility to mutations from tobacco carcinogen DNA adducts. …

Oxidative DNA base modifications and polycyclic aromatic hydrocarbon DNA adducts in squamous cell carcinoma of larynx

P Jałoszyński, P Jaruga, R Oliński, W Biczysko… - Free radical …, 2003 - Taylor & Francis
DNA lesions and aromatic DNA adducts, six modified DNA … level of PAH-related DNA adducts
were measured in cancerous and … The levels of oxidative DNA lesions in cancerous and …

In vitro BPDE‐induced DNA adducts in peripheral lymphocytes as a risk factor for squamous cell carcinoma of the head and neck

D Li, PF Firozi, P Chang, LE Wang… - … journal of cancer, 2001 - Wiley Online Library
… to cancer risk.19, 20 In this study of squamous cell carcinoma of the head and neck, we
provide further supporting evidence that the BPDE-induced DNA adduct … -related cancers. Data …

In vitro Benzo[a]pyrene Diol Epoxide–Induced DNA Adducts and Risk of Squamous Cell Carcinoma of Head and Neck

D Li, LE Wang, P Chang, AK El-Naggar, EM Sturgis… - Cancer research, 2007 - AACR
… developed the in vitro carcinogen-induced adduct assay that can be measured under the …
DNA adduct levels in cultured peripheral lymphocytes and found that such induced adduct

DNA adducts, mutations and cancer

K Hemminki - Carcinogenesis, 1993 - academic.oup.com
… of DNA adducts. A vivid history of the development of ideas on chemical causes of cancer
… In two other studies on squamous cell carcinomas lower frequencies ofp53 mutations were …

DNA adducts-chemical addons

TR Rajalakshmi, N AravindhaBabu… - Journal of Pharmacy …, 2015 - journals.lww.com
… , cancer is the second most common cause of death. Among cancers, squamous cell carcinoma
of … Instead of performing the whole body analysis for diagnosing cancer, DNA adduct test …

Prediction of treatment outcome by cisplatin‐DNA adduct formation in patients with stage III/IV head and neck squamous cell carcinoma, treated by concurrent cisplatin …

FJP Hoebers, D Pluim, M Verheij… - … journal of cancer, 2006 - Wiley Online Library
… higher adduct levels (p = 0.06). In conclusion, cisplatin-DNA adduct formation in primary tumor
… No differences were observed in intratumoral adduct levels between IA and IV treatments, …

Tobacco carcinogen metabolites and DNA adducts as biomarkers in head and neck cancer: potential screening tools and prognostic indicators

SS Khariwala, D Hatsukami, SS Hecht - Head & neck, 2012 - Wiley Online Library
… Head and neck squamous cell carcinoma (HNSCC) is one of many cancers that are
strongly associated with tobacco use. Whereas HNSCC is often seen in tobacco users, many …

Reduced DNA repair capacity for removing tobacco carcinogen–induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics

LE Wang, Z Hu, EM Sturgis, MR Spitz, SS Strom… - Clinical cancer …, 2010 - AACR
DNA repair phenotype as a genetic susceptibility biomarker for squamous cell carcinoma of
… excision repair in the etiology of squamous cell carcinoma of head and neck, and could be …

Safrole-like DNA adducts in oral tissue from oral cancer patients with a betel quid chewing history

CL Chen, CW Chi, KW Chang, TY Liu - Carcinogenesis, 1999 - academic.oup.com
… Betel quid (BQ) chewing has been associated with an increased risk of oral squamous
cell carcinoma (OSCC) and oral submucous fibrosis (OSF). Piper betle inflorescence, which …