Formaldehyde-induced DNA adducts as biomarkers of in vitro human nasal epithelial cell exposure to formaldehyde

W Zhong, SSQ Hee - Mutation Research/Genetic Toxicology and …, 2004 - Elsevier
… FA is a mutagen that causes nasal squamous cell carcinomas in rats at high air concentrations
beyond 6 ppm (v/v) in chronic exposures [3], [4], [5]. FA in air has also caused cancer in …

… [a] pyrene diol epoxide‐induced DNA damage and chromosomal aberrations in primary lymphocytes, smoking, and risk of squamous cell carcinoma of the head and …

P Xiong, Z Hu, C Li, LE Wang… - … journal of cancer, 2007 - Wiley Online Library
… Benzo[a]pyrene, a classic DNA-damaging carcinogen found … can induce DNA damage
including DNA adducts through … that DNA repair capacity (DRC) exist to protect the DNA from …

[HTML][HTML] Determinants of oxidative stress and DNA damage (8-OhdG) in squamous cell carcinoma of head and neck

A Kumar, MC Pant, HS Singh… - … Journal of Cancer, 2012 - journals.lww.com
… This redox imbalance appears to have a marked effect on DNA oxidation (DNA adduct) one
… a significant role of oxidative stress in squamous cell carcinoma of head and neck. Saliva …

[PDF][PDF] Investigation of NQO1 genetic polymorphism, NQO1 gene expression and PAH-DNA adducts in ESCC. A case-control study from Iran

HA Marjani, F Biramijamal, N Rakhshani… - Genetics and …, 2010 - academia.edu
… on PAH-DNA adducts in esophageal squamous cell carcinoma (ESCC) in northeast Iran.
Golestan Province in northeast of Iran has one of the highest esophageal cancer incidences in …

Immunoperoxidase detection of polycyclic aromatic hydrocarbon-DNA adducts in oral mucosa cells of smokers and nonsmokers.

YJ Zhang, TM Hsu, RM Santella - … of the American Association for Cancer …, 1995 - AACR
… diol epoxide-DNA adducts has been developed for the detection and quantitation of DNA
damage in single cells. The method was used initially on 10T1/2 cells treated with [3H]anti-…

[HTML][HTML] Selective decrease in the DNA base excision repair pathway in squamous cell cancer of the esophagus

P Bonde, D Gao, L Chen, M Duncan, T Miyashita… - The Journal of thoracic …, 2007 - Elsevier
… to harmful DNA adduct formation, of which 8-oxoG is the most stable and deleterious adduct.
This has been shown to lead to mismatch in base pairs by polymerases during the DNA

Implications of acetaldehyde-derived DNA adducts for understanding alcohol-related carcinogenesis

S Balbo, PJ Brooks - Biological Basis of Alcohol-Induced Cancer, 2015 - Springer
… of acetaldehyde-DNA adducts was covered in a recent review [8], here we will focus more
specifically on the major DNA adduct formed from the reaction of acetaldehyde with DNA, N 2 -…

Metabolic activation and carcinogen-DNA adduct detection in human larynx

M Degawa, SJ Stern, MV Martin, FP Guengerich, PP Fu… - Cancer research, 1994 - AACR
… as a causative factor for squamous cell carcinomas of the larynx (1), … DNA adducts, and
on concomitant genotypic and phenotypic changes in the pathogenesis of laryngeal cancer

Detection of DNA adducts in human oral tissue: correlation of adduct levels with tobacco smoking and differential enhancement of adducts using the butanol extraction …

NJ Jones, AD McGregor, R Waters - Cancer research, 1993 - AACR
… adduction to DNA in the squamous cell epithelia of individuals with oral cancer. Biopsies of
… of a composite resection for intraoral squamous cell carcinoma, have been studied from pa …

Mutagen sensitivity: enhanced risk assessment of squamous cell carcinoma

J Cloos, CBA Reid, GB Snow, BJM Braakhuis - European Journal of Cancer …, 1996 - Elsevier
… clastogenicity and DNA adducts in rats. Mutat Res 1991, 250, 87-93. Izzotti A, Balansky R,
Scatolini L, Rovida A, Deflora S. Inhibition by N-acetylcysteine of carcinogen-DNA adducts in …