Background Pseudomonas aeruginosa (PA) strains with defective DNA mismatch repair
genes generate numerous bacterial variants because of high mutation rates. In cystic fibrosis (…

… in one isolate, demonstrating that early host adaptation is characterized by the reduction of
… genome of this highly adapted pathogenic strain of P. aeruginosa to strengthen the genetic …

… Pseudomonas aeruginosa is an opportunistic pathogen … Due to a range of mechanisms
for adaptation, survival and … evaluate physiological adaptations at each stage of infection …

… Intense genome sequencing of Pseudomonas aeruginosa … -to-patient transmission of
adapted clones. However, genome … aeruginosa isolates from several patients with early-stage …

… Pseudomonas aeruginosa is the most prevalent … aeruginosa at each stage of infection
development in CF lungs. The comprehensive understanding of the adaptation process of P…

… Pseudomonas aeruginosa is commonly isolated from the airways of patients with CF, where
… Here, we discuss how P. aeruginosa evolves from a state of early, recurrent intermittent …

… pinpoint size (MT19) under antibiotic pressure at early stage could be understood as an
attempt of P. aeruginosa to adapt to the harmful conditions imposed. We hypothesized that these …

… Common loss-of-function mutations in genes such as lasR, mucA and mexT lead to a
general adaptation pattern and P. aeruginosa variants with increased antimicrobial resistance, …

… characterized, this study identified the phenotypic changes most associated with stage of P.
… did not assay, because of the difficulty of adapting those assays for high-throughput testing, …

… clinical isolates of Pseudomonas aeruginosa sampled from 34 children and young
individuals with cystic fibrosis. Our analysis of 36 P. aeruginosa lineages identified convergent …