[HTML][HTML] Neoadjuvant EGFR-TKI therapy for EGFR-mutant NSCLC: a systematic review and pooled analysis of five prospective clinical trials

L Sun, YJ Guo, J Song, YR Wang, SL Zhang… - Frontiers in …, 2021 - frontiersin.org
… In the present study, the pooled median PFS and OS for neoadjuvant EGFR-TKIs in the
stage IIIA group were 13.2 and 41.9 months, respectively, but median PFS values varied …

Effect of epidermal growth factor receptor gene mutation on the prognosis of pathological stage II–IIIA (TNM classification) primary lung cancer after curative surgery

T Isaka, H Ito, H Nakayama, T Yokose, H Saito… - Lung Cancer, 2021 - Elsevier
… In this study, the 5-year OS rates for p-stage II EGFR-Mt and p-stage IIIA EGFR-Mt were 92.0…
EGFR mutation was not an independent prognostic factor for OS of patients with p-stage IIIA

Positive EGFR mutation status is a risk of recurrence in pN0–1 lung adenocarcinoma when combined with pathological stage and histological subtype: A retrospective …

M Ito, Y Miyata, Y Tsutani, H Ito, H Nakayama, K Imai… - Lung Cancer, 2020 - Elsevier
… Univariate analysis showed SUV, lymphovascular invasion, pleural invasion, intrapulmonary
metastasis, LN metastasis, pStage IIAIIIA, and positive EGFR mutation status were risk of …

[HTML][HTML] Overview of current systemic management of EGFR-mutant NSCLC

WH Hsu, JCH Yang, TS Mok, HH Loong - Annals of Oncology, 2018 - Elsevier
… inhibitor (EGFR TKI) therapy is the standard of care for lung cancer patients with sensitising
EGFR mutations (exon 19 deletion or L858R mutation). Several phase III studies have …

[HTML][HTML] Role of consolidation durvalumab in patients with EGFR-and HER2-mutant unresectable stage III NSCLC

JA Hellyer, JV Aredo, M Das, K Ramchandran… - Journal of Thoracic …, 2021 - Elsevier
stage III NSCLC were treated with consolidation durvalumab. Of these patients, 14 had tumor
mutations in the ERBB family including 11 EGFR … of ERBB2/EGFR-mutant stage III NSCLC. …

[HTML][HTML] Brief report: durvalumab after chemoradiotherapy in unresectable stage III EGFR-mutant NSCLC: a post hoc subgroup analysis from PACIFIC

J Naidoo, S Antonia, YL Wu, BC Cho… - Journal of Thoracic …, 2023 - Elsevier
stage III NSCLC who have not progressed after chemoradiotherapy, on the basis of data from
the phase 3 … of immunotherapy in patients with stage III EGFR-mutant (EGFRm) NSCLC is …

[HTML][HTML] Genomic signatures define three subtypes of EGFR-mutant stage II–III non-small-cell lung cancer with distinct adjuvant therapy outcomes

SY Liu, H Bao, Q Wang, WM Mao, Y Chen… - Nature …, 2021 - nature.com
The ADJUVANT study reported the comparative superiority of adjuvant gefitinib over
chemotherapy in disease-free survival of resected EGFR-mutant stage II–IIIA non-small cell lung …

[HTML][HTML] Postoperative chemotherapy use and outcomes from ADAURA: osimertinib as adjuvant therapy for resected EGFR-mutated NSCLC

YL Wu, T John, C Grohe, M Majem, JW Goldman… - Journal of Thoracic …, 2022 - Elsevier
… In the phase 2 EVAN trial, Chinese patients with resected stage IIIA EGFRm NSCLC were
randomly assigned to either erlotinib or vinorelbine plus cisplatin chemotherapy. Furthermore, …

[HTML][HTML] Phase II study of biomarker-guided neoadjuvant treatment strategy for IIIA-N2 non-small cell lung cancer based on epidermal growth factor receptor mutation …

W Zhong, X Yang, H Yan, X Zhang, J Su… - Journal of Hematology & …, 2015 - Springer
… have shown that neoadjuvant EGFR-TKI therapy results in N2 downstaging in patients …
stage IIIA-N2 NSCLC harboring EGFR mutation [9–12]. In two phase II studies, neoadjuvant EGFR

… Growth Factor Receptor (EGFR) Mutation Testing for Patients With Advanced Non–Small-Cell Lung Cancer Considering First-Line EGFR Tyrosine Kinase Inhibitor …

VL Keedy, S Temin, MR Somerfield… - Journal of clinical …, 2011 - ascopubs.org
EGFR mutation status for erlotinib in a phase III trial from China (OPTIMAL) showed similar
results to IPASS. There have been no completed phase III … analyses of EGFR mutation testing …