[HTML][HTML] Identification of biomarkers for hepatocellular carcinoma using network-based bioinformatics methods

L Zhang, Y Guo, B Li, J Qu, C Zang, F Li… - European journal of …, 2013 - Springer
… molecular mechanisms of HCC, and to identify biomarkers for early diagnosis of HCC, we
… as M-phase promoting factor, which is essential for G1/S and G2/M phase transitions of the …

Applying NGS data to find evolutionary network biomarkers from the early and late stages of hepatocellular carcinoma

YH Wong, CC Wu, CL Lin, TS Chen… - BioMed Research …, 2015 - Wiley Online Library
networks (PPINs) for early-stage and late-stage liver cancer. By comparing the networks of
these two stages, we found that the two networksnetwork structures between cancer and …

Identifying novel biomarkers in hepatocellular carcinoma by weighted gene co‐expression network analysis

B Li, K Pu, X Wu - Journal of cellular biochemistry, 2019 - Wiley Online Library
… Validation of the gene expression levels between hepatocellular carcinoma (HCC) sample
and normal tissue from Gene Expression Profiling Interactive Analysis online database …

A network biology approach to discover the molecular biomarker associated with hepatocellular carcinoma

L Zhuang, Y Wu, J Han, X Ling, L Wang… - BioMed research …, 2014 - Wiley Online Library
biomarker used in the early stage of HCC will greatly lead to improved survival of patients. …
biomarkers from PPI network data, therefore, we should control the size of obtained networks

[HTML][HTML] Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma

B Yang, M Li, W Tang, W Liu, S Zhang, L Chen… - Nature …, 2018 - nature.com
biomarkers that can detect the tipping point before metastasis of hepatocellular carcinoma
(… To discover such early-warning signals or biomarkers of pulmonary metastasis in HCC, we …

Identifying critical states of hepatocellular carcinoma based on landscape dynamic network biomarkers

Y Sun, H Zhao, M Wu, J Xu, S Zhu, J Gao - Computational biology and …, 2020 - Elsevier
… are no specific symptoms in the early stages of HCC. This fact … methods (such as dynamic
network biomarkers, DNB) can be … based on landscape dynamic network biomarkers (L-DNB), …

[HTML][HTML] Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for hepatocellular carcinoma

J Long, Y Bai, X Yang, J Lin, X Yang, D Wang… - Cancer cell …, 2019 - Springer
… These ncRNAs act as ceRNAs to modulate mRNA expression and regulate protein levels
network because our network was based on rigorous processes. First, we included only cancer-…

[HTML][HTML] Identification of biomarkers for Barcelona Clinic Liver Cancer staging and overall survival of patients with hepatocellular carcinoma

W Xu, Q Rao, Y An, M Li, Z Zhang - PLoS One, 2018 - journals.plos.org
network analysis to identify interactions among hub genes, UALCAN analysis to assess gene
expression levels based on tumour stage, … We identified several candidate biomarkers that …

Discovering pathway biomarkers of hepatocellular carcinoma occurrence and development by dynamic network entropy analysis

C Shen, Y Cao, G Qi, J Huang, ZP Liu - Gene, 2023 - Elsevier
… 1 illustrates our proposed framework for identifying pathway biomarkers of HCC by
entropic dynamics from multi-stage transcriptome and interactome. To screen pathway …

[HTML][HTML] A new strategy for analyzing time-series data using dynamic networks: identifying prospective biomarkers of hepatocellular carcinoma

X Huang, J Zeng, L Zhou, C Hu, P Yin, X Lin - Scientific reports, 2016 - nature.com
… To trace the continuous changes of the most important interfacial stage between pre-cancer
CIR and early HCC, networks DN-4 (T 4 –T 5 ) and DN-5 (T 5 –T 6 ) representing the cases …