… As cell penetration is a critical property of stapled peptides, … of stapled peptide properties with
the capacity for cellular uptake… that stapled peptides, including some stapled versions of the …

… to the cell membrane. We show herein that stapled peptides can be rendered highly cell-permeable
by conjugating a cyclic cell-penetrating peptide to their N-terminus, C-terminus, …

… to afford high levels of cell penetration, and of those that are cell-penetrant; to our
knowledge, only one has been demonstrated safe and efficacious in vivo. That class, all-hydrocarbon-…

… Here, we compare four amphiphilic stapled peptides with their linear counterparts in terms
of their membrane binding and conformational features in order to correlate these with uptake …

… helicity and cell penetrating efficiency. … stapled peptide F-3 with CF, in which the stapling
structure was introduced at Gly residues, formed a stable α-helical structure and the highest cell…

… Stapled peptides consist of peptide chains that bring an external brace that force the peptide
… The capacity of cell penetration is directly linked to some peptide properties, such as the …

… We envision that implementing these design principles will expedite the advancement of
cell-penetrating stapled peptides with on-mechanism biological and therapeutic activities. …

… (44) So far, strict rules for the implementation of cell permeability have not … cellular uptake
of more than 200 stapled peptides revealed that cell penetration is mainly depending on staple …

… atoms, in contrast to all other previously reported designs which bore heteroatoms that
we viewed as probable impediments to efficient cell penetration. The all-hydrocarbon …

… a stapled peptide inhibitor that targets the interaction between β-catenin and T cell factor/…
learned from cell-penetrating peptide (CPP) design to maximize cellular uptake resulting in …