… In fact, the specific cellular role of STAT3 seems to be … , STAT3 can act both as a potent
tumor promoter or tumor suppressor factor. This implies that the therapies based on STAT3 …

… STAT3 have been used for a long time for treatment of many types of cancers like leukemia,
melanoma, colon, and renal cancer… STAT3 and used in treatment of different types of cancer. …

… STAT3, and its implications for comprehension of the protein functional mechanism and the
development of novel anticancer therapies. … recently demonstrated that STAT3 also localizes …

… Stat3 as a novel molecular target for cancer drug discovery has been well described …
Consideration of Stat3 as a target for anti-cancer drug design is based upon the findings that Stat3 …

… have been pursued to target STAT3, and we highlight some … an anticancer drug that might
therapeutically inhibit the STAT3 … anticancer drug that might therapeutically inhibit the STAT3 …

… role in a variety of cancers and inhibitors of STAT3 are used in pre-clinical and … STAT3 and
pancreatic cancer and the latest results on the use of STAT3 inhibitors in pancreatic cancer, …

… In normal healthy cells, STAT3 is tightly regulated to maintain a momentary active state. …
STAT3 has been observed in many different cancers and constitutively activated STAT3 has …

… develop direct STAT3 as a target for cancer therapy and will … STAT3 as a cancer therapy
target, the rationale to pursue the protein for the discovery and development of novel anticancer …

… strongly justifies the role of STAT3 inhibition as anticancer therapy, but the relative lack …
STAT3-targeted therapeutics. With few exceptions, oncogene-addiction to single pathway STAT3 …

… The current evidence strongly defends the role of STAT3 inhibition as antitumor agent, …
STAT3-targeted anticancer therapeutic agents. With few exceptions, clinical use of single STAT3 …