The multifaced role of STAT3 in cancer and its implication for anticancer therapy
M Tolomeo, A Cascio - International journal of molecular sciences, 2021 - mdpi.com
… In fact, the specific cellular role of STAT3 seems to be … , STAT3 can act both as a potent
tumor promoter or tumor suppressor factor. This implies that the therapies based on STAT3 …
tumor promoter or tumor suppressor factor. This implies that the therapies based on STAT3 …
STAT3 transcription factor as target for anti-cancer therapy
… STAT3 have been used for a long time for treatment of many types of cancers like leukemia,
melanoma, colon, and renal cancer… STAT3 and used in treatment of different types of cancer. …
melanoma, colon, and renal cancer… STAT3 and used in treatment of different types of cancer. …
Structural biology of STAT3 and its implications for anticancer therapies development
J Sgrignani, M Garofalo, M Matkovic, J Merulla… - International journal of …, 2018 - mdpi.com
… STAT3, and its implications for comprehension of the protein functional mechanism and the
development of novel anticancer therapies. … recently demonstrated that STAT3 also localizes …
development of novel anticancer therapies. … recently demonstrated that STAT3 also localizes …
Targeting Stat3 in cancer therapy
N Jing, DJ Tweardy - Anti-cancer drugs, 2005 - journals.lww.com
… Stat3 as a novel molecular target for cancer drug discovery has been well described …
Consideration of Stat3 as a target for anti-cancer drug design is based upon the findings that Stat3 …
Consideration of Stat3 as a target for anti-cancer drug design is based upon the findings that Stat3 …
[HTML][HTML] STAT3 signaling: anticancer strategies and challenges
PA Johnston, JR Grandis - Molecular interventions, 2011 - ncbi.nlm.nih.gov
… have been pursued to target STAT3, and we highlight some … an anticancer drug that might
therapeutically inhibit the STAT3 … anticancer drug that might therapeutically inhibit the STAT3 …
therapeutically inhibit the STAT3 … anticancer drug that might therapeutically inhibit the STAT3 …
STAT3 inhibitors: a novel insight for anticancer therapy of pancreatic cancer
X Li, W Jiang, S Dong, W Li, W Zhu, W Zhou - Biomolecules, 2022 - mdpi.com
… role in a variety of cancers and inhibitors of STAT3 are used in pre-clinical and … STAT3 and
pancreatic cancer and the latest results on the use of STAT3 inhibitors in pancreatic cancer, …
pancreatic cancer and the latest results on the use of STAT3 inhibitors in pancreatic cancer, …
Two decades of research in discovery of anticancer drugs targeting STAT3, how close are we?
JD Beebe, JY Liu, JT Zhang - Pharmacology & therapeutics, 2018 - Elsevier
… In normal healthy cells, STAT3 is tightly regulated to maintain a momentary active state. …
STAT3 has been observed in many different cancers and constitutively activated STAT3 has …
STAT3 has been observed in many different cancers and constitutively activated STAT3 has …
Small molecule inhibitors of STAT3 for cancer therapy
M Zhao, B Jiang, FH Gao - Current medicinal chemistry, 2011 - ingentaconnect.com
… develop direct STAT3 as a target for cancer therapy and will … STAT3 as a cancer therapy
target, the rationale to pursue the protein for the discovery and development of novel anticancer …
target, the rationale to pursue the protein for the discovery and development of novel anticancer …
Do STAT3 inhibitors have potential in the future for cancer therapy?
ALA Wong, JL Hirpara, S Pervaiz, JQ Eu… - Expert opinion on …, 2017 - Taylor & Francis
… strongly justifies the role of STAT3 inhibition as anticancer therapy, but the relative lack …
STAT3-targeted therapeutics. With few exceptions, oncogene-addiction to single pathway STAT3 …
STAT3-targeted therapeutics. With few exceptions, oncogene-addiction to single pathway STAT3 …
STAT3 and apoptosis challenges in cancer
… The current evidence strongly defends the role of STAT3 inhibition as antitumor agent, …
STAT3-targeted anticancer therapeutic agents. With few exceptions, clinical use of single STAT3 …
STAT3-targeted anticancer therapeutic agents. With few exceptions, clinical use of single STAT3 …
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