… SIRT6 in suppressing STAT3 to prevent cardiomyocyte hypertrophy. In the cardiomyocytes-…
STAT3 and its phosphorylated level were significantly decreased (Figs. 4A, B). Likewise, the …

… directly and suppress its degradation by suppressing K48-type … led to enhanced cardiomyocyte
hypertrophy and cardiac … STAT1 under hypertrophic stress compared with the basal state (…

… STAT3 in inducing cardiac myocyte hypertrophy was designed to both overexpress and inhibit
STAT3 activity in cardiac myocytes… suppressed even in the cells that overexpressed STAT3…

… -model is consistent with a protective role of phosphorylated-STAT3 in adult … The STAT3
pathway plays a role in the hypertrophy of atria and fibrogenesis. In our study, the cardiomyocyte …

… Thus, activation of AMPKα by STAT3 suppression may also improve mitochondrial and
myocardial energetics, protein homeostasis, and attenuation of cardiomyocyte hypertrophy …

… whether LIF induces cardiomyocyte hypertrophy and transmits … in primary cultured neonatal
rat cardiomyocytes. LIF increased … Preincubation with anti-STAT1 and anti-STAT3 antibodies …

… Downstream events linking STAT3 activation to cardiac hypertrophy … mediated gene regulation
in vivo, and suppressed Src-… -1 stimulate cardiac myocyte hypertrophy and promote cell …

… Furthermore, when MAPK activation was inhibited, gene expression and protein synthesis
were significantly suppressed even in the cells that overexpressed STAT3. The JAK-STAT …

… Supporting these in vivo observations, our in vitro studies also demonstrated that FNDC5
inhibits PA-induced cardiomyocytes hypertrophy via inactivated JAK2/STAT3 signaling-related …

… of cardiomyocytes, we further explored whether STAT3 … suppressed by STAT3 inhibition or
knock down. Intriguingly, the … of STAT3 significantly impaired the anti-hypertrophic effects of …