… to published reports of stem cell clinical trials and excludes the very substantial literature
on hematopoietic (blood) stem cells and associated gene therapies and cancer cell therapies. …

… safety challenges they may raise. “Tissue repair” for heart failure will be taken as a case study
since it illustrates most of these challenges … mechanism of action of the transplanted cells. …

… A main challenge in cell-based skeletal therapies is optimal cell sourcing. Current options …
allogeneic tissue-specific cells, adult multipotent stem cells, and pluripotent stem cells (PSCs). …

… Human Wharton's jelly stem cells (WJSC) from the umbilical cord matrix which are of … stem
cell types have to overcome before stem cell-based therapy becomes a genuine reality. J. Cell…

… stem-cell-like subset of cancer cells has been identified in many malignancies. These cells,
referred to as cancer stem cells … and therefore represent the cell population that drives growth …

… stem cells (MSCs) are considered as promising source of stem cells in personalized cell-…
The inherent tumor-tropic property of MSCs can be used to target cancer cells. Although the …

… stem cells (ESC) are wholly resolved, perhaps hESC can become superior to the existing
stem cell sources… the standard and promising applications of cell and tissue-based therapeutic …

… a solid clinical translation. For this reason, our aim was to dissect the current challenges
in the development of still promising cell … Stem Cells Translational Medicine 2019;8:1135–1148 …

… However, any clinical trial approaches should be extensively supported by validated robust
… scientific and clinical challenges that need to be surmounted before any clinical application …

… cells of clinical grade quality. In this review, current methods in adipose tissue-derived stem
cell … for future applications in regenerative medicine and possible challenges along the way. …