… into 8-cell embryos, ciTotiSCs contributed to both embryonic and extraembryonic lineages
with high efficiency. Our chemical approach to totipotent stem cell induction and maintenance …

… In addition, cardiomyocyte-like cells can be generated by treating human fibroblasts with
several small molecular weight chemicals 8 . These chemicals can also expand adult stem cells …

… were treated with chemical cocktails in DMEM for two days. Then the culture medium was
switched into HSPC maintaining medium M5300 including cytokines stem cell factor (Scf), FMS…

… drug cocktails which promoted cell … stem cell characterization, GFP + embryonic stem
cell-like colonies were picked up and passaged on irradiated MEFs in mouse embryonic stem cell …

… stem cells, such as embryonic stem cells and induced pluripotent stem cells, and
transdifferentiation from somatic cells. … Recently, chemical induced direct cell reprogramming with …

… cell lines using retroviral transduction of the Yamanaka factors (Goh et al., 2013). In this study,
we investigated the effects of cocktail of chemical compounds (VCFZ) and recombinant cell…

… stem cell-mediated regenerative medicine is the development of defined culture systems for
the maintenance of clinical-grade human embryonic stem (hES) cells… our chemically defined …

… Chemically induced neural stem-like cells (ciNSLCs) generated with these compounds
were characterized and compared to other mouse NSC populations. The ciNSCLCs expressed …

… We find that this chemical cocktail-induced cell reprogramming crucially depends on
stepwise activation of a suite of growth factors and requires nucleoporin Nup210 to activate …

… one of the key beneficial niche features for stem cells in vivo 49 . Thus, it would be of great
interest to test whether these chemical cocktails could facilitate cell lineage conversion in vivo. …