… Finally, we discuss areas for improvement in creating next generation stem cell-… , stem
cell-derived hepatocyte-like cells could provide a sustainable cell source for: high-throughput drug …

… efficiency in drug development and chemical safety testing. … for personalized drug testing
based on stem cell and organ-on… to the replacement of animal testing. Particular focus will be …

… drug screens. This article discusses the opportunities and challenges for the use of stem cells
in drug … major pillars in the drug discovery process will be iPSC testing, animal testing and …

… and efficacy testing of drug candidates [8… stem cell-derived 3D culture models, organoids,
and organ-on-a-chip models, which are being developed as non-animal models for use in drug …

… of stem cells and cancer stem cells in drug screening and their role in complementing, reducing,
and replacing animal testing. … organ will be a gold standard for single organ drug testing. …

… drug discovery (Fig. 1). While this article focuses on hiPSCs and toxicity screening, other stem
cell … understanding of toxicity pathways in human cells and techniques for toxicity testing. …

… stem cell–derived cardiomyocytes (hESC-CMs) assessed with a combination of single cell
… can serve as a novel model for electrophysiological drug screening. Current-clamp studies …

… It is perhaps not surprising that positive results obtained in preclinical drug testing are not
replicated in the diverse human population if they are based on imperfect model systems — for …

… of differentiated cells, including goblet and endocrine cells. … cell proliferation, which we used
as a platform for drug testing. … FAP-COs, but also affected cell proliferation in wild-type COs, …

… In 2001, the ECVAM Scientific Advisory Board approved an embryonic stem cell test (EST)
as a scientifically validated test for embryotoxicity in vitro 84,85 . This group recommended …