Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods

JM Churko, J Lee, M Ameen, M Gu… - Nature biomedical …, 2017 - nature.com
… pluripotent stem cells (hiPSCs) that closely resemble human embryonic stem cells (hESCs).
This has led to assessments of how similar hiPSCs are to hESCs, by evaluating differences

Epigenetic differences between naïve and primed pluripotent stem cells

S Takahashi, S Kobayashi, I Hiratani - Cellular and Molecular Life …, 2018 - Springer
… These pluripotent cells possess features that distinguish them from mouse embryonic stem
cells (mESCs). It was an exciting time for the field of stem cell research, as many groups were …

Human DNA methylomes at base resolution show widespread epigenomic differences

R Lister, M Pelizzola, RH Dowen, RD Hawkins, G Hon… - nature, 2009 - nature.com
… In the H1 stem cells we detected abundant DNA methylation in non-CG contexts (mCHG
and mCHH, where H = A, C or T), comprising almost 25% of all cytosines at which DNA …

Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease

A Rada-Iglesias, J Wysocka - Genome medicine, 2011 - Springer
… Although differences arising as a result of experimental … in epigenomics can be used to
gain insight into human development and disease, and to facilitate the transition of stem cell

[HTML][HTML] The epigenomics of embryonic stem cell differentiation

DC Kraushaar, K Zhao - International journal of biological sciences, 2013 - ncbi.nlm.nih.gov
stem cells could now be generated with a possibility for autologous regenerative transplants.
Since then, we have come to understand that the epigenome of somatic cellsdifferences in …

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

R Lister, M Pelizzola, YS Kida, RD Hawkins, JR Nery… - Nature, 2011 - nature.com
… distinct from ES cells, insofar as they manifest common, … epigenomic differences. Continued
study of a wide variety of ES cells is needed to understand the full range of epigenomic

Epigenomic analysis of multilineage differentiation of human embryonic stem cells

W Xie, MD Schultz, R Lister, Z Hou, N Rajagopal… - Cell, 2013 - cell.com
… , we differentiated human embryonic stem cells into mesendoderm, neural progenitor cells,
trophoblast-like cells, and mesenchymal stem cells and systematically characterized DNA …

[HTML][HTML] Distinct epigenomic landscapes of pluripotent and lineage-committed human cells

RD Hawkins, GC Hon, LK Lee, QM Ngo, R Lister… - Cell stem cell, 2010 - cell.com
… how much epigenomes differ remains unclear. Here, we report that epigenomic landscapes
in … At least two models account for differences between pluripotent stem cells and lineage-…

[HTML][HTML] Epigenetic variation between human induced pluripotent stem cell lines is an indicator of differentiation capacity

M Nishizawa, K Chonabayashi, M Nomura, A Tanaka… - Cell stem cell, 2016 - cell.com
… Variation in the differentiation capacity of induced pluripotent stem cells (iPSCs) to specific
lineages … Transposition of native chromatin for fast and sensitive epigenomic profiling of open …

Stable methylation at promoters distinguishes epiblast stem cells from embryonic stem cells and the in vivo epiblasts

AC Veillard, H Marks, AS Bernardo… - Stem cells and …, 2014 - liebertpub.com
… the epigenome of the primed EpiSCs clearly differ from that of the naïve ESCs. The differences
in promoter methylation in the two pluripotent cell … with the differences in expression of the …