Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods
… pluripotent stem cells (hiPSCs) that closely resemble human embryonic stem cells (hESCs).
This has led to assessments of how similar hiPSCs are to hESCs, by evaluating differences …
This has led to assessments of how similar hiPSCs are to hESCs, by evaluating differences …
Epigenetic differences between naïve and primed pluripotent stem cells
S Takahashi, S Kobayashi, I Hiratani - Cellular and Molecular Life …, 2018 - Springer
… These pluripotent cells possess features that distinguish them from mouse embryonic stem
cells (mESCs). It was an exciting time for the field of stem cell research, as many groups were …
cells (mESCs). It was an exciting time for the field of stem cell research, as many groups were …
Human DNA methylomes at base resolution show widespread epigenomic differences
… In the H1 stem cells we detected abundant DNA methylation in non-CG contexts (mCHG
and mCHH, where H = A, C or T), comprising almost 25% of all cytosines at which DNA …
and mCHH, where H = A, C or T), comprising almost 25% of all cytosines at which DNA …
Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease
A Rada-Iglesias, J Wysocka - Genome medicine, 2011 - Springer
… Although differences arising as a result of experimental … in epigenomics can be used to
gain insight into human development and disease, and to facilitate the transition of stem cell …
gain insight into human development and disease, and to facilitate the transition of stem cell …
[HTML][HTML] The epigenomics of embryonic stem cell differentiation
DC Kraushaar, K Zhao - International journal of biological sciences, 2013 - ncbi.nlm.nih.gov
… stem cells could now be generated with a possibility for autologous regenerative transplants.
Since then, we have come to understand that the epigenome of somatic cells … differences in …
Since then, we have come to understand that the epigenome of somatic cells … differences in …
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
… distinct from ES cells, insofar as they manifest common, … epigenomic differences. Continued
study of a wide variety of ES cells is needed to understand the full range of epigenomic …
study of a wide variety of ES cells is needed to understand the full range of epigenomic …
Epigenomic analysis of multilineage differentiation of human embryonic stem cells
… , we differentiated human embryonic stem cells into mesendoderm, neural progenitor cells,
trophoblast-like cells, and mesenchymal stem cells and systematically characterized DNA …
trophoblast-like cells, and mesenchymal stem cells and systematically characterized DNA …
[HTML][HTML] Distinct epigenomic landscapes of pluripotent and lineage-committed human cells
… how much epigenomes differ remains unclear. Here, we report that epigenomic landscapes
in … At least two models account for differences between pluripotent stem cells and lineage-…
in … At least two models account for differences between pluripotent stem cells and lineage-…
[HTML][HTML] Epigenetic variation between human induced pluripotent stem cell lines is an indicator of differentiation capacity
M Nishizawa, K Chonabayashi, M Nomura, A Tanaka… - Cell stem cell, 2016 - cell.com
… Variation in the differentiation capacity of induced pluripotent stem cells (iPSCs) to specific
lineages … Transposition of native chromatin for fast and sensitive epigenomic profiling of open …
lineages … Transposition of native chromatin for fast and sensitive epigenomic profiling of open …
Stable methylation at promoters distinguishes epiblast stem cells from embryonic stem cells and the in vivo epiblasts
AC Veillard, H Marks, AS Bernardo… - Stem cells and …, 2014 - liebertpub.com
… the epigenome of the primed EpiSCs clearly differ from that of the naïve ESCs. The differences
in promoter methylation in the two pluripotent cell … with the differences in expression of the …
in promoter methylation in the two pluripotent cell … with the differences in expression of the …
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