… trials involving human embryonic stem cells and the widely transplanted mesenchymal stem
… Standard of Care (SoC) must consider the long-term effects of genetic instability and gene …

… and tumor cells in general. In this review, we summarize the current concepts of stem cells
and cancer stem cells, draw attention to the current understanding of genetic instability in …

… An important question is whether iPSCs would present the same genetic instability as hESCs?
Future stem cell-based therapy is likely to rely more on iPSCs than on ESCs, both for legal…

… Genetic and epigenetic instabilities among stem cells have been a recurring obstacle to …
using stem cells. Various reports have stated that these instabilities can transform stem cells …

… stem cells (PSCs), whether embryonic stem cells or induced pluripotent stem cells, are subject
to continual genetic … speed with which novel genetic variants can become predominant in …

… Genetically altered iPS cells can grow out and dominate the cell culture. This review intends
to comprehensively summarize the current knowledge on genetic instability of embryonic …

… that human pluripotent stem cells (hPSCs) are prone to (epi)genetic instability during in vitro
… on culture-induced (epi)genetic alterations in hPSCs and their phenotypic consequences. …

… Genetic instability has been recognized as a hallmark of human cancers. … genetic instability.
Aneuploidy, chromosome structural rearrangements, centrosome amplification, and gene …

… DNA replication stress and genomic instability, explaining the high frequency … stem cell
reprogramming also leads to genomic instability. To test this hypothesis, we examined stem cells …

… mutations, when cells affected by genetic instability continue to … or other forms of genomic
instability to their daughter cells. … We used cells from genetically defined inbred FVB/N mice, …