… genomic stability of all analyzed hESC and hiPSC lines under identical culture conditions).
Moreover, the results of a genomic stability … genomic stability of various pluripotent cell lines. …

… In the promising era of stem cell research and therapy, ensuring genomic stability of stem
cells remains one of the highest priorities prior to clinical translation. In this review, we provide …

Pluripotent stem cell (PSC) cultures are subjected to selective pressures that can result in
acquisition and expansion of recurrent genetic abnormalities at any time. These recurrent …

… genomic stability in cardiac and embryonic stem cells. Karyotypic abnormalities in primary
human cardiac stem cells … in cardiac stem cells and in human embryonic stem cells revealed a …

… on several intrinsic (cell-autonomous) and extrinsic (non–cell-… ) and disruptions of genomic
stability can impair HSC functions. … the maintenance of genomic stability affect HSC functions. …

… pluripotent stem cells (iPSCs), mesenchymal stem cells (… of the in vitro manipulated stem
cells are determined by the … that influence the genomic stability of stem cells thus impeding the …

… Also, it remains to be clarified the acceptable threshold number of passages able to grant
the maintenance of genomic stability, or at least, able to guarantee that despite any lesions …

… placed to develop more efficient protocols for inducing stem cells, care must be taken that
increased efficiency is not achieved at the expense of genomic stability. For example, c-Myc …

… Oxygen concentration is another parameter found to influence genomic stability of stem
cells. … Quantification of DNA damage in cardiac stem cells and in human ESCs revealed a …

… the most significant mutagens in stem cells, when elevated, activate … stem cell differentiation.
Based on studies performed primarily on hematopoietic stem cells and embryonic stem cells…