[HTML][HTML] Role of stem cells in human uterine leiomyoma growth

M Ono, W Qiang, VA Serna, P Yin, JS Coon, A Navarro… - PloS one, 2012 - journals.plos.org
… of putative stem/reservoir cells that support growth exists within the leiomyoma. In support
of this hypothesis, the Hoechst-stained cells contained a small fraction of SP cells that were …

Uterine leiomyoma stem cells: linking progesterone to growth

SE Bulun, MB Moravek, P Yin, M Ono… - Seminars in …, 2015 - thieme-connect.com
… a myometrial stem cell or simply support already existing leiomyoma stem-progenitor … stem
cells markers CD49b and CD34 in leiomyoma SP cells compared with main population cells

Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications

MB Moravek, P Yin, M Ono, JS Coon V… - Human reproduction …, 2015 - academic.oup.com
… of stem cells and their paracrine interactions with more differentiated cell populations within
leiomyoma has … therapeutics that temper leiomyoma growth and those that eradicate them. …

[HTML][HTML] Current understanding of somatic stem cells in leiomyoma formation

A Mas, I Cervello, C Gil-Sanchis, C Simón - Fertility and sterility, 2014 - Elsevier
… with somatic stem cell self-renewal and cell growth by the … By characterizing the putative
leiomyoma stem cell population, … These cells are likely to be vulnerable to developing mutations …

Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth

M Ono, P Yin, A Navarro, MB Moravek… - Proceedings of the …, 2013 - National Acad Sciences
… These observations indicate that unique interactions exist between β-catenin activation,
estrogen and progesterone action, and growth via stem cell renewal; we hypothesize that these …

Tissue-specific stem cells in the myometrium and tumor-initiating cells in leiomyoma

M Ono, SE Bulun, T Maruyama - Biology of reproduction, 2014 - academic.oup.com
… There is increasing evidence that steroid hormones are the most important regulators affecting
the growth of leiomyomas [65]. Growth of leiomyoma stem cells requires the presence of …

Paracrine pathways in uterine leiomyoma stem cells involve insulinlike growth factor 2 and insulin receptor A

MB Moravek, P Yin, JS Coon, M Ono… - The Journal of …, 2017 - academic.oup.com
leiomyoma stem cells … of leiomyoma cells, including leiomyoma stem cells, as well as
evidence on the importance of IGF2 signaling and IR-A in leiomyoma stem cells and tumor growth. …

[PDF][PDF] Stem cells and uterine leiomyomas: What is the evidence

MM Carneiro - JBRA Assist Reprod, 2016 - researchgate.net
… may help establish the missing link between the development of treatments designed to
stop the growth of leiomyomas and therapies devised to eliminate them. Therefore, this study …

Developmental exposure to endocrine disruptors expands murine myometrial stem cell compartment as a prerequisite to leiomyoma tumorigenesis

A Mas, L Stone, PM O'Connor, Q Yang, D Kleven… - Stem Cells, 2017 - academic.oup.com
… Moreover, MyoF stem cells grow faster than MyoN in vitro and expressed altered levels of DNA
… that notion, as growth factors and inflammation promote stem cell expansion and mediate …

Human uterine leiomyoma stem/progenitor cells expressing CD34 and CD49b initiate tumors in vivo

P Yin, M Ono, MB Moravek, JS Coon… - The Journal of …, 2015 - academic.oup.com
leiomyoma cells exhibiting stem cell characteristics. However, unless mixed with mature
myometrial cells, these leiomyoma side population cells … hormones on leiomyoma growth (19). …