[HTML][HTML] Role of stem cells in human uterine leiomyoma growth
M Ono, W Qiang, VA Serna, P Yin, JS Coon, A Navarro… - PloS one, 2012 - journals.plos.org
… of putative stem/reservoir cells that support growth exists within the leiomyoma. In support
of this hypothesis, the Hoechst-stained cells contained a small fraction of SP cells that were …
of this hypothesis, the Hoechst-stained cells contained a small fraction of SP cells that were …
Uterine leiomyoma stem cells: linking progesterone to growth
SE Bulun, MB Moravek, P Yin, M Ono… - Seminars in …, 2015 - thieme-connect.com
… a myometrial stem cell or simply support already existing leiomyoma stem-progenitor … stem
cells markers CD49b and CD34 in leiomyoma SP cells compared with main population cells…
cells markers CD49b and CD34 in leiomyoma SP cells compared with main population cells…
Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications
MB Moravek, P Yin, M Ono, JS Coon V… - Human reproduction …, 2015 - academic.oup.com
… of stem cells and their paracrine interactions with more differentiated cell populations within
leiomyoma has … therapeutics that temper leiomyoma growth and those that eradicate them. …
leiomyoma has … therapeutics that temper leiomyoma growth and those that eradicate them. …
[HTML][HTML] Current understanding of somatic stem cells in leiomyoma formation
… with somatic stem cell self-renewal and cell growth by the … By characterizing the putative
leiomyoma stem cell population, … These cells are likely to be vulnerable to developing mutations …
leiomyoma stem cell population, … These cells are likely to be vulnerable to developing mutations …
Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth
M Ono, P Yin, A Navarro, MB Moravek… - Proceedings of the …, 2013 - National Acad Sciences
… These observations indicate that unique interactions exist between β-catenin activation,
estrogen and progesterone action, and growth via stem cell renewal; we hypothesize that these …
estrogen and progesterone action, and growth via stem cell renewal; we hypothesize that these …
Tissue-specific stem cells in the myometrium and tumor-initiating cells in leiomyoma
M Ono, SE Bulun, T Maruyama - Biology of reproduction, 2014 - academic.oup.com
… There is increasing evidence that steroid hormones are the most important regulators affecting
the growth of leiomyomas [65]. Growth of leiomyoma stem cells requires the presence of …
the growth of leiomyomas [65]. Growth of leiomyoma stem cells requires the presence of …
Paracrine pathways in uterine leiomyoma stem cells involve insulinlike growth factor 2 and insulin receptor A
MB Moravek, P Yin, JS Coon, M Ono… - The Journal of …, 2017 - academic.oup.com
… leiomyoma stem cells … of leiomyoma cells, including leiomyoma stem cells, as well as
evidence on the importance of IGF2 signaling and IR-A in leiomyoma stem cells and tumor growth. …
evidence on the importance of IGF2 signaling and IR-A in leiomyoma stem cells and tumor growth. …
[PDF][PDF] Stem cells and uterine leiomyomas: What is the evidence
MM Carneiro - JBRA Assist Reprod, 2016 - researchgate.net
… may help establish the missing link between the development of treatments designed to
stop the growth of leiomyomas and therapies devised to eliminate them. Therefore, this study …
stop the growth of leiomyomas and therapies devised to eliminate them. Therefore, this study …
Developmental exposure to endocrine disruptors expands murine myometrial stem cell compartment as a prerequisite to leiomyoma tumorigenesis
… Moreover, MyoF stem cells grow faster than MyoN in vitro and expressed altered levels of DNA
… that notion, as growth factors and inflammation promote stem cell expansion and mediate …
… that notion, as growth factors and inflammation promote stem cell expansion and mediate …
Human uterine leiomyoma stem/progenitor cells expressing CD34 and CD49b initiate tumors in vivo
P Yin, M Ono, MB Moravek, JS Coon… - The Journal of …, 2015 - academic.oup.com
… leiomyoma cells exhibiting stem cell characteristics. However, unless mixed with mature
myometrial cells, these leiomyoma side population cells … hormones on leiomyoma growth (19). …
myometrial cells, these leiomyoma side population cells … hormones on leiomyoma growth (19). …
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