Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis

L He, T He, J Xing, Q Zhou, L Fan, C Liu… - Stem cell research & …, 2020 - Springer
… the effect of bone marrow mesenchymal stem cell (BMSC)-derived exosome injection on
cartilage damage and pain relief in both in vitro and in vivo models of osteoarthritis (OA). …

[HTML][HTML] Osteoarthritis and stem cell therapy in humans: a systematic review

DS Jevotovsky, AR Alfonso, TA Einhorn… - Osteoarthritis and …, 2018 - Elsevier
… Other sequelae included pain, swelling and dehydration after aspiration 15 . A more recent
… of autologous stem cell therapies found they primarily included post-procedural pain or pain

[HTML][HTML] Mesenchymal stem cells in osteoarthritis therapy: a review

C Zhu, W Wu, X Qu - American journal of translational research, 2021 - ncbi.nlm.nih.gov
… The main goals of traditional medication and biological agents in OA treatment are relief of
pain and slowing down or halting of the progress of OA. Stem cell-based therapy is of great …

The effect of intra‐articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis

D Garay‐Mendoza, L Villarreal‐Martínez… - … journal of rheumatic …, 2018 - Wiley Online Library
Aim Management of osteoarthritis ( OA ) is basically symptomatic. Recently, stem cells ( SC )
have been used in the search for an optimum treatment. We decided to conduct a controlled …

[HTML][HTML] Mechanisms of analgesic effect of mesenchymal stem cells in osteoarthritis pain

F Almahasneh, E Abu-El-Rub… - … Journal of Stem Cells, 2023 - ncbi.nlm.nih.gov
… A clinical trial of autologous bone marrow stem cells (BM-SC) concluded that a single IA
injection of these stem cells significant reduced knee pain and improved quality of life[67]. Other …

Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study

L Orozco, A Munar, R Soler, M Alberca, F Soler… - …, 2013 - journals.lww.com
… feasibility and safety of osteoarthritis treatment with mesenchymal stromal cells (MSCs) in …
Our results suggest that MSC treatment improves pain and other clinical signs and, in some …

Mesenchymal stem cells reduce pain but not degenerative changes in a mono‐iodoacetate rat model of osteoarthritis

GM van Buul, M Siebelt, MJC Leijs… - Journal of …, 2014 - Wiley Online Library
stem cells (MSCs), as well as freshly isolated bone marrow mononuclear cells (BMMNCs),
on pain, cartilage damage, bone changes and inflammation in an in-vivo rat osteoarthritis (OA…

Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients

F Davatchi, BS Abdollahi, M Mohyeddin… - … journal of rheumatic …, 2011 - Wiley Online Library
… and at successive controls: pain on VAS, time to walk to produce pain, number of stairs to
climb to produce pain, the resting time to induce the gelling pain, the range of motion, the …

New approaches to treat osteoarthritis with mesenchymal stem cells

K Shah, AG Zhao, H Sumer - Stem Cells International, 2018 - Wiley Online Library
Osteoarthritis is one of the most common chronic health problems in the world that causes
disability and chronic pain … , pharmacological intervention for pain management, and surgical …

Mesenchymal stem cell secretome reduces pain and prevents cartilage damage in a murine osteoarthritis model

S Khatab, G van Osch, N Kops… - European cells & …, 2018 - repub.eur.nl
stem cells (MSCs) represent a promising biological therapeutic option as an osteoarthritis
(OA)-… repair cells. The effects of intra-articular injection of MSC secretome on OA-related …