… from individuals with the brittle bone disorder osteogenesis imperfecta, demonstrating
successful gene targeting in adult human stem cells. Osteogenesis imperfecta (OI) is caused by …

… Pre- and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis
imperfecta: a two-center experience. Stem Cells Transl Med. 2014;3(2):255–64. https://doi.org/…

… Osteogenesis imperfecta (OI) is a disease caused by mutations in different genes resulting …
use of cell therapy to correct the underlying molecular defects of OI. Mesenchymal stem cells (…

… osteogenesis imperfecta (OI) with mesenchymal stem cells (MSCs). MSCs ability to migrate,
engraft, and differentiate into bone cells … tissues makes these cells promising candidates as …

… in selection of the appropriate stem cell type and preparation will be … stem cell transplantation
for OI is still a highly experimental therapy. From experience in other fields of stem cell …

… Also, in the Brtl mouse model for classic osteogenesis imperfecta, which is heterozygous
for an α1(I) Gly349Cys substitution, mesenchymal stem cells, precursors to both osteoblasts …

… Figure 1COL1A2 gene targeting in osteogenesis imperfecta mesenchymal stem cells (OI
MSCs). (a) Schematic representation of the gene-targeting vector AAV-COL2e4INloxpA shown …

… Figure 1Stem cell engineering strategy for osteogenesis imperfecta (OI). Schematic
representation of proposed therapeutic approach for OI based on autologous, gene-targeted, …

… fetal MSC as the donor cell source for the intrauterine transplantation, hypothesizing that
they propagate better than adult MSC in the fetal environment. Osteogenesis imperfecta (OI) is …

… cell for mesenchymatous tissues can be isolated from marrow or periosteum. This cell, referred
to as a Mesenchymal Stem Cell … tissues have reasonably high cellular turnover rates. If …