Paracrine mechanisms in adult stem cell signaling and therapy

M Gnecchi, Z Zhang, A Ni, VJ Dzau - Circulation research, 2008 - Am Heart Assoc
… factors may mediate endogenous regeneration via activation of resident cardiac stem cells.
Furthermore, cardiac remodeling, contractility, and metabolism may also be influenced in a …

Paracrine effects of mesenchymal stem cells on the activation of keratocytes

Z Jiang, G Liu, F Meng, W Wang, P Hao… - British Journal of …, 2017 - bjo.bmj.com
stem cell (MSC)-derived soluble factors on the function of keratocytes, with a particular focus
on the processes involved in wound healing, including keratocyte activation, … The paracrine

Paracrine mechanisms of stem cell reparative and regenerative actions in the heart

M Mirotsou, TM Jayawardena, J Schmeckpeper… - … of molecular and cellular …, 2011 - Elsevier
… to the paracrine regenerative capacity of MSCs by activation of … The evidence for stem
cell-derived paracrine factors … forward in our understanding of stem cell biology. Identifying which …

Activation of cardiac progenitor cells through paracrine effects of mesenchymal stem cells

C Nakanishi, M Yamagishi, K Yamahara… - Biochemical and …, 2008 - Elsevier
… in a paracrine manner. Recent reports have suggested that cardiac progenitor cells (CPC)
reside in the heart. In this study, we investigated whether MSC had paracrine effects on CPC …

Surgically relevant aspects of stem cell paracrine effects

PR Crisostomo, TA Markel, Y Wang, DR Meldrum - Surgery, 2008 - surgjournal.com
activate transplanted stem cells, resident stem cells, and injured … stem cell-driven repair
process. Although our understanding of the mechanistic basis for stem cell-mediated paracrine

ATP autocrine/paracrine signaling induces calcium oscillations and NFAT activation in human mesenchymal stem cells

S Kawano, K Otsu, A Kuruma, S Shoji, E Yanagida… - Cell calcium, 2006 - Elsevier
… mesenchymal stem cells (hMSCs) have the potential to differentiate into several types of
cells. … We also found that an ATP autocrine/paracrine signaling pathway is involved in the …

Paracrine effect of inflammatory cytokine-activated bone marrow mesenchymal stem cells and its role in osteoblast function

C Li, G Li, M Liu, T Zhou, H Zhou - Journal of bioscience and …, 2016 - Elsevier
… In this study, we found that the paracrine effects of immunomodulatory-activated MSCs
significantly promoted the proliferation and migration of osteoblasts and stimulated osteoblast …

Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth

M Ono, P Yin, A Navarro, MB Moravek… - Proceedings of the …, 2013 - National Acad Sciences
… signal from estrogen/progesterone receptor-rich mature cells to activate the canonical β-catenin
pathway in leiomyoma stem cells. Our findings suggest a paracrine role for the …

[HTML][HTML] Mesenchymal stem cell paracrine factors in vascular repair and regeneration

D Pankajakshan, DK Agrawal - Journal of biomedical technology …, 2014 - ncbi.nlm.nih.gov
… migration and angiogenesis [40], as well as in the activation of endogenous stem cells. The
local delivery of both the IGF-1 and HGF in the infarcted heart resulted in the migration of c-kit…

Role of stem-cell-derived microvesicles in the paracrine action of stem cells

G Camussi, MC Deregibus… - Biochemical Society …, 2013 - portlandpress.com
paracrine/endocrine hypothesis of stem cell action is thus based on these observations and
suggests that factors produced and secreted by stem cells … in stem cells and the activation of …