Evidence for a β-adrenergic receptor initiating DNA synthesis in haemopoietic stem cells
JW Byron - Experimental Cell Research, 1972 - Elsevier
… of p-adrenergic receptors, is a potent initiator of DNA synthesis in haemopoietic stem cells. …
CFU-S from a resting (GO) state into cell cycle, or to shorten the cell cycle of CFU-S. The low …
CFU-S from a resting (GO) state into cell cycle, or to shorten the cell cycle of CFU-S. The low …
DNA damage in stem cells
… cells, which would be particularly detrimental to the whole organism. Inducible pluripotent
stem cells also display a robust DNA … by the mutational history of the cell population of origin, …
stem cells also display a robust DNA … by the mutational history of the cell population of origin, …
The role of DNA damage repair in aging of adult stem cells
J Kenyon, SL Gerson - Nucleic acids research, 2007 - academic.oup.com
… Of note, NHEJ proteins are also involved in VDJ recombination, a process in T and B cells
of generating diversity in the T-cell receptor and B-cell heavy chain loci. During this process, …
of generating diversity in the T-cell receptor and B-cell heavy chain loci. During this process, …
DNA damage response and resistance of cancer stem cells
E Abad, D Graifer, A Lyakhovich - Cancer Letters, 2020 - Elsevier
… plasticity, which is required for the maintenance of breast cancer cell stemness [68]. The …
of adult stem cells and in chemoresistant phenotype of cancer cells. All Notch receptors and …
of adult stem cells and in chemoresistant phenotype of cancer cells. All Notch receptors and …
[HTML][HTML] Critical role for the DNA sensor AIM2 in stem cell proliferation and cancer
… deficient mice; however, intestinal stem cells were prone to uncontrolled proliferation. Aberrant
Wnt signaling expanded a population of tumor-initiating stem cells in the absence of AIM2…
Wnt signaling expanded a population of tumor-initiating stem cells in the absence of AIM2…
Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage
PA Crawford, Y Sadovsky… - Molecular and cellular …, 1997 - Am Soc Microbiol
… We demonstrate that mutants which disrupt the DNA binding domain or the AF2
transcriptional activation domain of SF-1 do not confer the steroidogenic phenotype to ES cells. …
transcriptional activation domain of SF-1 do not confer the steroidogenic phenotype to ES cells. …
Stem cells: balancing resistance and sensitivity to DNA damage
JC Liu, PH Lerou, G Lahav - Trends in cell biology, 2014 - cell.com
… stem cells to DNA damage and propose multiple regulatory networks that may affect the
sensitivity of adult stem cells … The intrinsic apoptotic pathway is non-receptor-mediated and relies …
sensitivity of adult stem cells … The intrinsic apoptotic pathway is non-receptor-mediated and relies …
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
AM Bröske, L Vockentanz, S Kharazi, MR Huska… - Nature …, 2009 - nature.com
… stem cell fate remains unknown. Here, we show that alternative functional programs of
hematopoietic stem cells … Several surface receptors expressed on differentiated cells, but normally …
hematopoietic stem cells … Several surface receptors expressed on differentiated cells, but normally …
Human adipose-tissue derived mesenchymal stem cells induce functional de-novo regulatory T cells with methylated FOXP3 gene DNA
AU Engela, MJ Hoogduijn, K Boer… - Clinical & …, 2013 - academic.oup.com
… , mesenchymal stem cells (MSC) are interesting candidates for cellular … of effector T cells and
induce T cells with a regulatory … Interleukin (IL)-2 receptor blocking prevented this induction. …
induce T cells with a regulatory … Interleukin (IL)-2 receptor blocking prevented this induction. …
DNA repair defects in stem cell function and aging
Y Park, SL Gerson - Annu. Rev. Med., 2005 - annualreviews.org
… DSBs can also be created by a malfunction of recombination-activating gene complex
during V(D)J recombination in T and B lymphocytes, which creates T cell receptor and …
during V(D)J recombination in T and B lymphocytes, which creates T cell receptor and …
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