Pluripotency inducing Yamanaka factors: role in stemness and chemoresistance of liver cancer

H Fatma, HR Siddique - Expert Review of Anticancer Therapy, 2021 - Taylor & Francis
… the role of OSKM in inducing pluripotency and stem cell-like … Yamanaka factors’ role in
stemness and chemoresistance of … of the major reasons for stemness and drug resistance and is …

Nicotine-induced ILF2 facilitates nuclear mRNA export of pluripotency factors to promote stemness and chemoresistance in human esophageal cancer

Y Li, M Wang, M Yang, Y Xiao, Y Jian, D Shi, X Chen… - Cancer Research, 2021 - AACR
This study defines a previously uncharacterized role of nicotine-regulated ILF2 in facilitating
nuclear mRNA export to promote cancer stemness, suggesting a potential therapeutic …

Understanding the molecular mechanisms that regulate pancreatic cancer stem cell formation, stemness and chemoresistance: a brief overview

GP Nagaraju, B Farran, T Luong… - Seminars in Cancer …, 2023 - Elsevier
… Research indicates that CDK1 can directly influence the function of various pluripotency
factors such as Nanog, Sox2, and Oct4. The CDK1/cyclin A complex can phosphorylate Nanog, …

[HTML][HTML] Chemotherapy-induced adenosine A2B receptor expression mediates epigenetic regulation of pluripotency factors and promotes breast cancer stemness

J Lan, G Wei, J Liu, F Yang, R Sun, H Lu - Theranostics, 2022 - ncbi.nlm.nih.gov
factor FOXO3 activates expression of pluripotency factors in response to chemotherapy in
… in A2BR-induced pluripotency factor expression in response to chemotherapy, we searched …

[HTML][HTML] The role of pluripotency factors to drive stemness in gastrointestinal cancer

M Müller, PC Hermann, S Liebau, C Weidgang… - Stem cell …, 2016 - Elsevier
… Various other OCT4-dependent mechanisms are thought to be involved in chemoresistance.
… an important role in tumor-associated chemoresistance and suggests that inhibition of the …

[HTML][HTML] CPEB1 mediates hepatocellular carcinoma cancer stemness and chemoresistance

M Xu, S Fang, J Song, M Chen, Q Zhang, Q Weng… - Cell death & …, 2018 - nature.com
… The mRNA expression and protein levels of the major pluripotency factors OCT4, NANOG,
SOX2 and LIN28 were all reduced in response to CPEB1 overexpression, significantly for …

Induction of cancer cell stemness by chemotherapy

X Hu, L Ghisolfi, AC Keates, J Zhang, S Xiang, D Lee… - Cell cycle, 2012 - Taylor & Francis
… We demonstrate that carboplatin can induce the self-renewal (spherogenesis) and
pluripotency (Sox2 and oct3/4 expression) of hepatocellular carcinoma (HCC) cells grown under …

[HTML][HTML] Can stemness and chemoresistance be therapeutically targeted via signaling pathways in ovarian cancer?

L Roy, KD Cowden Dahl - Cancers, 2018 - mdpi.com
pluripotency factors common in ovarian CSCs including OCT4, MYC, and ARID3B will provide
clarity for how cancer stemness … pathways involved in stemness and chemoresistance, we …

[HTML][HTML] Intrinsic and extrinsic factors impacting cancer stemness and tumor progression

A Ponomarev, Z Gilazieva, V Solovyeva, C Allegrucci… - Cancers, 2022 - mdpi.com
Pluripotency factors and signaling pathways, which regulate and modulate cancer stemness
are … of stemness factor genes and increased drug resistance [134]. Finally, tumor necrosis …

[HTML][HTML] Snail transcription factors as key regulators of chemoresistance, stemness and metastasis of ovarian cancer cells

M Kielbik, P Przygodzka, I Szulc-Kielbik… - Biochimica et Biophysica …, 2023 - Elsevier
… stem cells, significantly affects drug resistance acquisition. Transcription factors in the Snail
family have been implicated in ovarian cancer chemoresistance and metastasis. In this article…