[HTML][HTML] Assessment of the antitumor potentiality of newly designed steroid derivatives: Pre-clinical study

DS El-Kady, NA Ali, AH Sayed… - Asian Pacific Journal …, 2019 - ncbi.nlm.nih.gov
… In conclusion, this study introduced a facile synthesis of new hybrid steroid derivatives in …
moieties to the steroid nucleus in order to produce effective anticancer agents. Compounds 3, 4 …

Synthesis, pharmacological evaluation and docking studies of progesterone and testosterone derivatives as anticancer agents

M Jabeen, MI Choudhry, GA Miana, KM Rahman… - Steroids, 2018 - Elsevier
… Compounds 6, 23, and 31 were almost similar in exhibiting anticancer potentials attaining
IC 50 values of10.09 ± 0.21, 10.43 ± 0.71 and 10.01 ± 0.13 μM respectively. In comparison, …

Therapeutic value of steroidal alkaloids in cancer: Current trends and future perspectives

P Dey, A Kundu, HJ Chakraborty, B Kar… - … journal of cancer, 2019 - Wiley Online Library
… the anticancer activity of natural steroidal alkaloids and their synthetic and semi-synthetic
derivatives. … the anticancer potentials and mechanisms of action of SAs are currently available. …

Anticancer potential of brassinosteroids

OV Panibrat, VN Zhabinskii, VA Khripach - Brassinosteroids: Plant Growth …, 2019 - Springer
… The cytotoxicity of 22,23-oxygenated stigmastanes depended on the number and structure
of substituents in the steroid skeleton. The 3β-hydroxy-5-ene derivatives were more toxic than …

Therapeutic potential of steroidal alkaloids in cancer and other diseases

QW Jiang, MW Chen, KJ Cheng, PZ Yu… - Medicinal research …, 2016 - Wiley Online Library
… the anticancer profiles both in vitro and in vivo of steroidal alkaloids such as dendrogenin,
solanidine, solasodine, tomatidine, cyclopamine, and their derivatives. … potentials of steroidal

[HTML][HTML] New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin

C Cheng, J Wang, J Chen, KT Kuo, J Tang… - Cancer Cell …, 2019 - Springer
… Huachansu and its major derivative, Bufalin, had been found to possess anti-cancer effects
steroidal cardiac glycosides in animal studies. In this review article, data on the anti-cancer

[HTML][HTML] Pharmacological modulation of steroid activity in hormone-dependent breast and prostate cancers: effect of some plant extract derivatives

B Bayala, AA Zoure, S Baron, C de Joussineau… - International journal of …, 2020 - mdpi.com
… SGLXD also has anti-tumor effects on the BCa cells ZR-75-1 by inhibiting aromatase and
steroid sulfatase [88]. Butein, a natural chalcone found in Toxicodendron vernicifluum, shows …

[HTML][HTML] Natural product triterpenoids and their semi-synthetic derivatives with potential anticancer activity

Y Ren, AD Kinghorn - Planta Medica, 2019 - thieme-connect.com
anticancer potential is summarized for naturally occurring triterpenoids and their semi-synthetic
derivativesanticancer potentials of the representative compound, (+)-cucurbitacin D (18). …

Pd-catalyzed Suzuki–Miyaura couplings and evaluation of 13α-estrone derivatives as potential anticancer agents

R Jójárt, H Ali, G Horváth, Z Kele, I Zupkó, E Mernyák - Steroids, 2020 - Elsevier
13α-Estrones are of great value owing to their potent multiple bioactivity, including anticancer
activity. 3-OH or 3-OBn derivatives of 2- or 4-[(subst.) phenyl]-13α-estrone as potential …

Synthesis of new steroidal quinolines with antitumor properties

YT Yang, S Du, S Wang, X Jia, X Wang, X Zhang - Steroids, 2019 - Elsevier
… to the steroid core may yield new steroidal quinolines with anticancer potentials. Herein, we
… the synthesis of new steroidal quinolines from DHEA and isatin derivatives via the Al 2 O 3 /…