Disruption of the steroid metabolome in fish caused by exposure to the environmental estrogen 17α-ethinylestradiol

AM Flores-Valverde, J Horwood… - Environmental science & …, 2010 - ACS Publications
steroid metabolome in animal tissues, allowing an investigation on the effect of estrogen
exposure a range of sex steroids … EE2 exposure on the steroid metabolome of sexually mature …

Responses in the crucian carp (Carassius auratus) exposed to environmentally relevant concentration of 17α-Ethinylestradiol based on metabolomics

X Zhou, Y Li, H Li, Z Yang, C Zuo - Ecotoxicology and Environmental Safety, 2019 - Elsevier
… Crucian carp were exposed to EE2 at environmentally … of the physiological endpoints, steroid
hormones, and metabolome. The … However, the mechanisms of estrogen-induced gonadal …

Methodology for Profiling the Steroid Metabolome in Animal Tissues Using Ultraperformance Liquid Chromatography− Electrospray-Time-of-Flight Mass Spectrometry

AM Flores-Valverde, EM Hill - Analytical chemistry, 2008 - ACS Publications
… in liver or testes, but ovarian extracts caused ion supression of estrogens. A comparison of
the steroid metabolome of the ovaries and testes using partial least-squares discrimination …

Microbial degradation of steroid sex hormones: implications for environmental and ecological studies

YR Chiang, STS Wei, PH Wang, PH Wu… - Microbial …, 2020 - Wiley Online Library
… Another example of interrogating environmental hormone degradation is using the 13 C-metabolomic
approach to identify major oestrogen degradation pathways in river waters. The …

[HTML][HTML] The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and …

TV Nguyen, JM Reuter, NW Gaikwad… - Translational …, 2017 - nature.com
… exposures to ovarian steroids. To test this, we used a steroid-based metabolomics platform to
… /P4 sensitivity) were confirmed by ovarian steroid manipulation. The main goal of this study …

Using NMR metabolomics to identify responses of an environmental estrogen in blood plasma of fish

LM Samuelsson, L Förlin, G Karlsson… - Aquatic toxicology, 2006 - Elsevier
metabolomics to compare blood plasma and plasma lipid extracts from rainbow trout exposed
to the synthetic contraceptive estrogen … knowledge of the effects of estrogens on fish. This …

Hepatic transcriptomic and metabolomic responses in the Stickleback (Gasterosteus aculeatus) exposed to ethinyl-estradiol

I Katsiadaki, TD Williams, JS Ball, TP Bean… - Aquatic toxicology, 2010 - Elsevier
… We report on the characterisation of stickleback responses to the model xenoestrogen
ethinyl-estradiol (EE 2 ), employing transcriptomics, metabolomics, and classical biomarkers such …

Metabolomic Response of Human Embryonic Stem Cell–Derived Germ-like Cells After Exposure to Steroid Hormones

FD West, WM Henderson, P Yu, JY Yang… - Toxicological …, 2012 - academic.oup.com
… the metabolomic response of the synthetic estrogen, ethinyl … metabolomic profiling of GLCs
is a useful analytical tool in investigating the biochemical fluxes following exposure to steroid

Ultra performance liquid chromatography-tandem mass spectrometry method for profiling of steroid metabolome in human tissue

NW Gaikwad - Analytical chemistry, 2013 - ACS Publications
… Overall presence of all major classes of steroids as well as estrogen derivatives was … of
steroid metabolome (Figure 1) composed of androgens, corticosteroids, progestogens, estrogens

Exposure to estrogenic mixtures results in tissue-specific alterations to the metabolome of oysters

R Islam, SD Melvin, RMK Yu, WA O'Connor, TKA Tran… - Aquatic Toxicology, 2021 - Elsevier
environmentally relevant mixtures of estrogens at levels representative of receiving waters on
the metabolome … Oysters were exposed to a “low” and a “high” mixture of (xeno) estrogens (…