High sensitive thyroglobulin assay on thyroxine therapy: can it avoid stimulation test in low and high risk differentiated thyroid carcinoma patients?

P Trimboli, D La Torre, L Ceriani… - Hormone and …, 2013 - thieme-connect.com
… suggest that TSH stimulation could be … assay under replacement therapy. The aim of this
study was to evaluate the need of Tg stimulation test in DTC followed-up by sensitive Tg assay. …

Serum basal thyroglobulin measured by a second-generation assay correlates with the recombinant human thyrotropin–stimulated thyroglobulin response in patients …

C Spencer, S Fatemi, P Singer, J Nicoloff, J LoPresti - Thyroid, 2010 - liebertpub.com
… ) stimulation is … ) thyroglobulin (b-Tg) is below the assay sensitivity limit. The objective of this
study was to determine relationships between the b-Tg and the 72-hour rhTSH-stimulated Tg …

Thyroglobulin measurement by highly sensitive assays: focus on laboratory challenges

L Giovanella, U Feldt-Rasmussen… - Clinical Chemistry and …, 2015 - degruyter.com
… Monitoring thyroglobuin in a sensitive immunoassay has comparable sensitivity to
recombinant human TSH-stimulated thyroglobulin in follow-up of thyroid cancer patients. J Clin …

A highly sensitive thyroglobulin assay has superior diagnostic sensitivity for recurrence of differentiated thyroid cancer in patients undergoing TSH suppression

K Zöphel, G Wunderlich, J Kotzerke - Journal of Nuclear Medicine, 2006 - Soc Nuclear Med
… conventional thyroglobulin assays and can measure serum thyroglobulin reliably and simply
in the follow-up of treated DTC patients without exogenous or endogenous TSH stimulation. …

Unstimulated highly sensitive thyroglobulin in follow-up of differentiated thyroid cancer patients: a meta-analysis

L Giovanella, G Treglia, R Sadeghi… - The Journal of …, 2014 - academic.oup.com
… Therefore, a Tg stimulation test can … assay ≥0.1 in a DTC patient with a negative stimulated
Tg and as false negative a basal hsTg assay <0.1 in a DTC patient with a positive stimulated

The use of ultrasensitive thyroglobulin assays reduces but does not abolish the need for TSH stimulation in patients with differentiated thyroid carcinoma

MG Castagna, HPT Jury, C Cipri, V Belardini… - Journal of …, 2011 - Springer
… To this purpose we performed an rhTSH stimulation test in patients with low detectable
basal Tg and we correlated the results with the clinical status of patients. This analysis showed …

Thyroglobulin (Tg) testing revisited: Tg assays, TgAb assays, and correlation of results with clinical outcomes

BC Netzel, SKG Grebe… - The Journal of …, 2015 - academic.oup.com
… with thyroglobulin (Tg) measurements, potentially resulting in false low results in Tg immunometric
assays … is variable between patients and Tg assays and is only loosely correlated with …

Monitoring thyroglobulin in a sensitive immunoassay has comparable sensitivity to recombinant human TSH-stimulated thyroglobulin in follow-up of thyroid cancer …

RC Smallridge, SE Meek, MA Morgan… - The Journal of …, 2007 - academic.oup.com
… periodically have a rhTSH stimulation test and that those whose Tg … stimulation. The purpose
of this study was to review our experience since 2001, when a more sensitive Tg assay with …

Thyroglobulin in differentiated thyroid cancer

C Evans, S Tennant, P Perros - Clinica Chimica Acta, 2015 - Elsevier
stimulating … of assays to recognise forms of Tg secreted by a tumour, assay biases and
not least the potential for interference in immunoassays for Tg from endogenous thyroglobulin

Technology Insight: measuring thyroglobulin and thyroglobulin autoantibody in patients with differentiated thyroid cancer

CA Spencer, JS LoPresti - Nature clinical practice Endocrinology & …, 2008 - nature.com
… of current thyroglobulin assays influence the clinical … thyroglobulin assays (functional
sensitivities ∼1.0 µg/l); 24 however, the PPV of a positive rhTSH-stimulation test (72-h thyroglobulin