… stromal cells, cancer associated fibroblasts (CAFs), and the ECM they produce, to highlight
the role of CAFs in tumorigenesis accounting for the Cancer … substantial stromal remodeling (…

… Approximately 80% of fibroblasts in breast cancer stroma acquire an aggressive phenotype
… revealed that active fibroblasts contribute to angiogenesis, ECM remodeling, inflammation …

… most solid tumors is dependent upon remodeling ‘stroma’, composed of cancer-associated …
identifying the stroma-dependent mechanisms that regulate cancer-associated inflammation …

… cancer. In the present work we investigated the role of normal and tumor-associated
fibroblasts. … In vitro models were used to throw light on the multifactorial process of tumor-stroma …

… , such as cancer-associated fibroblasts (CAFs), which are activated fibroblasts in the tumor
stroma, … of growth factors, cytokines, and chemokines in addition to remodeling of the ECM. …

… the stromal cells that populate the tumour microenvironment, cancer-associated fibroblasts
(… Desmoplasia is a dynamic stromal alteration whereby remodelling of the local ECM …

… Cancer-associated fibroblasts (CAFs) have emerged as key players among stromal cells, …
Although physical ECM remodeling is crucial to allow cancer cells’ migration, it has been …

… Cancer-associated fibroblasts (CAFs) are the largest population of stromal cells within breast
cancers … is the aberrant production and remodeling of ECM. ECM composition and CAF …

… Tumor stroma is often fibrotic and rich in fibrillar type I collagen and … -associated
fibroblasts (CAFs), also known as tumor-associated fibroblasts (TAFs), in creating a remodeling …

… stromal fibroblasts, cancer-associated fibroblasts and melanoma cells. When melanoma first
initiates, the quiescent fibroblasts in stroma create … -promoting properties, remodel the tumor …