… KPC models develop desmoplastic stroma, they do not develop desmoplastic stroma to the
… the reduction of collagen deposition and stromal remodeling in PDAC TME, and decreased …

… participate in tumor progression; they can be “educated” by cancer cells … cancer-associated
fibroblasts (CAFs); CAFs, in turn, remodel tumor stroma to be more advantageous for cancer …

… stroma with poor vascularity. Cellular components of the TME chiefly consist of cancer-associated
fibroblasts (… activation, as well as the stromal remodeling capacity of PSCs through a …

… tumor stromal milieu, heterogeneous populations of fibroblast-like cells, collectively termed
carcinoma-associated fibroblasts … as well as proteases that remodel it, adipocytes that act as …

… Tumor- or cancer-associated fibroblasts (CAFs) are one of the most abundant stromal cell
types in … Furthermore, CAFs play an important role in remodeling of the extracellular matrix by …

… abundant stromal cell population, cancer-associated fibroblasts (CAFs), promote cancer cell
… Next, we asked whether BM remodeling by CAFs makes it more permissive for cancer cell …

… of the tumor microenvironment (TME), especially its stromal … Cancer-associated fibroblasts
(CAFs) are the major components of the stromal region, providing material support for tumor …

… stromal cells, especially tumour-associated fibroblasts, within the TME as an adjuvant
therapy to sensitize immunosuppressive tumours and prevent cancer … of matrix remodelling in …

… To examine the interaction between cancer cells and the fibroblasts in the stroma, spheroids
consisting of mouse mammary epithelial cells EpH4-Ev, 67NR, or 4T1 were embedded in …

… cells from the stroma such as cancer-associated fibroblasts (CAFs) and tumor-associated …
considered as positive mediators of cancer progression and stromal remodeling [63] as well …