Clinical and therapeutic relevance of cancer-associated fibroblasts
… stroma develops with a profound desmoplastic reaction resulting in an abundance of fibrous
and/or connective tissue. In general, the tumour stroma is … , ECM remodelling and fibroblast …
and/or connective tissue. In general, the tumour stroma is … , ECM remodelling and fibroblast …
Cancer-associated fibroblasts: how do they contribute to metastasis?
MQ Kwa, KM Herum, C Brakebusch - Clinical & experimental metastasis, 2019 - Springer
… fibroblasts, also known as cancer-associated fibroblasts (… the stroma cell population and
contribute significantly to cancer … a marker for fibroblasts undergoing tissue remodeling but also …
contribute significantly to cancer … a marker for fibroblasts undergoing tissue remodeling but also …
Cancer associated fibroblasts in cancer pathogenesis
OE Franco, AK Shaw, DW Strand… - Seminars in cell & …, 2010 - Elsevier
… tumor microenvironment, variously referred to as cancer stroma, reactive stroma or
carcinoma-associated fibroblasts … cells, angiogenesis and ECM remodeling. This is coupled with …
carcinoma-associated fibroblasts … cells, angiogenesis and ECM remodeling. This is coupled with …
[HTML][HTML] Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer
TP Sandberg, MPME Stuart, J Oosting… - BMC cancer, 2019 - Springer
… of cancer-associated fibroblasts (CAFs) of which different subtypes are known. The aim of
this study is to investigate and quantify CAFs present in the tumor stroma … and remodeling the …
this study is to investigate and quantify CAFs present in the tumor stroma … and remodeling the …
[HTML][HTML] Direct interaction between carcinoma cells and cancer associated fibroblasts for the regulation of cancer invasion
H Yamaguchi, R Sakai - Cancers, 2015 - mdpi.com
… to the remodeling and stiffening of the stromal ECM, thereby … on the interaction between
stromal fibroblasts and scirrhous gastric … between cancer cells and stromal fibroblasts in cancer …
stromal fibroblasts and scirrhous gastric … between cancer cells and stromal fibroblasts in cancer …
[HTML][HTML] Cancer‑associated fibroblasts regulate the biological behavior of cancer cells and stroma in gastric cancer
Q Zhang, C Peng - Oncology Letters, 2018 - spandidos-publications.com
… of CAFs in cancer cell proliferation, cell migration, invasion, extracellular matrix remodeling,
… that the cross‑talk between CAF, cancer cells and tumor stroma promotes GC progression. …
… that the cross‑talk between CAF, cancer cells and tumor stroma promotes GC progression. …
[HTML][HTML] Profiling cancer-associated fibroblasts in melanoma
F Papaccio, D Kovacs, B Bellei, S Caputo… - International Journal of …, 2021 - mdpi.com
… in tumor growth and extracellular matrix remodeling implicated … shown that stromal cells
surrounding the cancer nest play a … Activated fibroblast, called cancer-associated fibroblast (CAF)…
surrounding the cancer nest play a … Activated fibroblast, called cancer-associated fibroblast (CAF)…
Diversity and biology of cancer-associated fibroblasts
G Biffi, DA Tuveson - Physiological reviews, 2020 - journals.physiology.org
… In cancer, the SASP of stromal cells has been reported to play various roles (147, 256), … and
stromal content. Indeed, ECM remodeling and deposition are not restricted to cancer, but are …
stromal content. Indeed, ECM remodeling and deposition are not restricted to cancer, but are …
[HTML][HTML] Cancer-associated fibroblasts from invasive breast cancer have an attenuated capacity to secrete collagens
Z Fu, P Song, D Li, C Yi, H Chen… - International …, 2014 - spandidos-publications.com
… In cancer tissue, the remodeling of stromal structure and tumor … of tumor cells and stromal
cells, the latter include fibroblasts, … Fibroblasts, termed cancer-associated fibroblasts (CAFs) …
cells, the latter include fibroblasts, … Fibroblasts, termed cancer-associated fibroblasts (CAFs) …
Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives
Z Fang, Q Meng, J Xu, W Wang, B Zhang… - Cancer …, 2023 - Wiley Online Library
… and safer stroma-targeted cancer … cancer, TGF-β signaling in fibroblasts was downregulated
by adenosine, which accelerated tumor progression and metastasis via ECM remodeling […
by adenosine, which accelerated tumor progression and metastasis via ECM remodeling […