The dark side of fibroblasts: cancer-associated fibroblasts as mediators of immunosuppression in the tumor microenvironment

L Monteran, N Erez - Frontiers in immunology, 2019 - frontiersin.org
… activates stromal fibroblasts, physiologically programmed to facilitate matrix remodeling
reprogramming of resident dermal fibroblasts, or of mesenchymal stromal cells in an NF-κB …

Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment

L Bu, H Baba, N Yoshida, K Miyake, T Yasuda… - Oncogene, 2019 - nature.com
… , cancer-associated fibroblasts (CAFs) are found in the tumor stroma of various cancers [4],
and … onset initiates the Ets2-dependent expression of ECM remodeling, wound healing, and …

Cancer-associated fibroblasts and resistance to anticancer therapies: status, mechanisms, and countermeasures

B Feng, J Wu, B Shen, F Jiang, J Feng - Cancer Cell International, 2022 - Springer
… adhesion of cancer cell integrins to stromal fibroblasts or to … -derived ECM remodeling and
cancer chemoresistance [52]. … the tumor stroma to create a physical barrier between cancer

[HTML][HTML] Cancer associated fibroblasts: the dark side of the coin

P Cirri, P Chiarugi - American journal of cancer research, 2011 - ncbi.nlm.nih.gov
tumor progression by promoting ECM remodelling, cell proliferation, angiogenesis and
EMT. … in prostate cancer stromal fibroblasts. CXCL14 increases both growth and migration of …

Epithelial‐to‐mesenchymal transition transcription factors in cancerassociated fibroblasts

J Baulida - Molecular oncology, 2017 - Wiley Online Library
… Similar fibroblasts, named cancer-associated fibroblast or … and biochemical remodelling of
the stromal extracellular matrix … Recently, Twist1-expressing stromal fibroblasts within cancer

Cancer-associated Fibroblast–specific Expression of the Matricellular Protein CCN1 Coordinates Neovascularization and Stroma Deposition in Melanoma Metastasis

J Hutchenreuther, J Nguyen, K Quesnel… - Cancer Research …, 2024 - AACR
… and remodeling of tumor stroma in a cancer model. This analysis tool may permit identification
of novel therapeutic targets or drugs aimed at remodeling cancer-associated fibrosis. The …

[HTML][HTML] Cancer-associated fibroblasts provide a stromal niche for liver cancer organoids that confers trophic effects and therapy resistance

J Liu, P Li, L Wang, M Li, Z Ge, L Noordam… - Cellular and molecular …, 2021 - Elsevier
… liver tumor–derived organoids with cancer-associated fibroblasts. … between tumor cells and
the stromal compartment and the … cancer cells and CAFs, we first explored the construction of …

Gene expression profile of stromal factors in cancer-associated fibroblasts from prostate cancer

N Eiro, JM Fernández-Gómez… - Diagnostics, 2022 - mdpi.com
… in cancer. The aim of the study was to contribute to the characterization of the phenotype of
cancer-associated fibroblasts (CAFs) in prostate cancer (… ADT-induced stromal remodeling is …

The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance

G Kharaishvili, D Simkova, K Bouchalova… - Cancer cell …, 2014 - Springer
… cell types within the tumor and its surrounding supportive tissue or tumor stroma [1]. Invasive
tumor cells interact with the microenvironment and remodel it into a milieu supportive of …

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors

UE Martinez-Outschoorn, S Pavlides… - Cell Cycle, 2010 - Taylor & Francis
… expression of stromal Cav-1 in cancer associated fibroblasts. We … Tumor cells induce the
cancer associated fibroblast … a loss of Cav-1 and stromal remodeling. In our co-culture model, …