Cancerassociated fibroblasts in breast cancer: Challenges and opportunities

D Hu, Z Li, B Zheng, X Lin, Y Pan, P Gong… - Cancer …, 2022 - Wiley Online Library
… , 22], thus remodeling the local TME by promoting tissue hardening and stromal cell fibrosis
[… NG2) in stromal cells of IDC and overexpression of fibroblast activation protein alpha (FAP), …

Expression of cancer-associated fibroblast-related proteins in adipose stroma of breast cancer

YY Jung, YK Lee, JS Koo - Tumor Biology, 2015 - Springer
Cancer-associated fibroblasts (CAFs) play key roles in tumor … This study aimed to evaluate
CAF-related protein expression … CAF-related proteins in adipose stroma of breast cancer and …

The action of discoidin domain receptor 2 in basal tumor cells and stromal cancer-associated fibroblasts is critical for breast cancer metastasis

CAS Corsa, A Brenot, WR Grither, S Van Hove… - Cell reports, 2016 - cell.com
tumor cells and primary tumor stromal cancer-associated fibroblasts (CAFs) is critical for
breast cancer metastasis in the mouse mammary tumor virus-polyoma middle T antigen (MMTV-…

Targeting cancer-associated fibroblasts: Challenges, opportunities and future directions

BH Jenkins, JF Buckingham, CJ Hanley… - Pharmacology & …, 2022 - Elsevier
cancer-associated fibroblasts (CAFs), which are one of the most abundant components of
tumour stroma. … has been shown to attenuate joint damage and inflammatory bone remodelling

[HTML][HTML] Cancer associated fibroblasts (CAFs) in tumor microenvironment

F Xing, J Saidou, K Watabe - Frontiers in bioscience: a journal and …, 2010 - ncbi.nlm.nih.gov
… Among all the stromal components, fibroblasts are essential to synthesize and deposit the
… The remodeling of the extracellular matrix by MMPs is one of the most crucial steps for …

Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression

E Pazolli, E Alspach, A Milczarek, J Prior… - Cancer research, 2012 - AACR
… ) remodeling enzymes that are highly reminiscent of factors expressed in cancer-associated
fibroblasts (… This expression profile is collectively referred to as the senescence-associated

[HTML][HTML] Heterogeneity and plasticity of cancer-associated fibroblasts in the pancreatic tumor microenvironment

LNC Boyd, KD Andini, GJ Peters, G Kazemier… - Seminars in cancer …, 2022 - Elsevier
… KPC models develop desmoplastic stroma, they do not develop desmoplastic stroma to the
… the reduction of collagen deposition and stromal remodeling in PDAC TME, and decreased …

Tumor-derived extracellular vesicles activate normal human fibroblasts to a cancer-associated fibroblast-like phenotype, sustaining a pro-tumorigenic …

I Giusti, M Di Francesco, G Poppa, L Esposito… - Frontiers in …, 2022 - frontiersin.org
… participate in tumor progression; they can be “educated” by cancer cells … cancer-associated
fibroblasts (CAFs); CAFs, in turn, remodel tumor stroma to be more advantageous for cancer

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma: an update on heterogeneity and therapeutic targeting

U Vaish, T Jain, AC Are, V Dudeja - International journal of molecular …, 2021 - mdpi.com
stroma with poor vascularity. Cellular components of the TME chiefly consist of cancer-associated
fibroblasts (… activation, as well as the stromal remodeling capacity of PSCs through a …

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

P Gascard, TD Tlsty - Genes & development, 2016 - genesdev.cshlp.org
tumor stromal milieu, heterogeneous populations of fibroblast-like cells, collectively termed
carcinoma-associated fibroblasts … as well as proteases that remodel it, adipocytes that act as …