Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies

N D'souza, F Rossignoli, G Golinelli, G Grisendi… - BMC medicine, 2015 - Springer
… The therapeutic promise of multipotent mesenchymal stem/stromal cells (MSC), a population
of adult stem cells that can differentiate into cells deriving from mesoderm lineage, is rising […

Extracellular matrix-modified fiber scaffolds as a proadipogenic mesenchymal stromal cell delivery platform

C Blum, K Schlegelmilch, T Schilling… - ACS biomaterials …, 2019 - ACS Publications
… to generate proadipogenic cell delivery platforms. The adipogenic differentiation of human
mesenchymal stromal cells (hMSCs) in vitro is commonly induced by treating the cells with …

Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform

BF Benabdallah, E Allard, S Yao, G Friedman… - …, 2010 - Taylor & Francis
… Gene-modified mesenchymal stromal cells (MSC) provide a promising tool for cell and
gene therapy-based applications by potentially acting as a cellular vehicle for protein-…

Immunotherapy by mesenchymal stromal cell delivery of oncolytic viruses for treating metastatic tumors

AR Yoon, C Rivera-Cruz, JM Gimble, CO Yun… - Molecular Therapy …, 2022 - cell.com
… We further provide potential pitfalls of the MSC-OV platform and the strategies under … strategy
for the delivery of cancer therapeutic agents is the use of mesenchymal stromal cells (MSCs…

Scaffold-based delivery of mesenchymal stromal cells to diabetic wounds

S Du, DI Zeugolis, T O'Brien - Stem Cell Research & Therapy, 2022 - Springer
… has been considered as the first choice cell delivery platform for diabetic wound healing.
Mouse bone marrow-derived MSCs (BM-MSCs) and AD-MSCs delivered with a type I rat tail …

Cell-based drug delivery platforms

JM Lanao, C Gutiérrez-Millán, CI Colino - Pharmaceutics, 2020 - mdpi.com
cells. This work demonstrates the potential utility of mesenchymal stem-cell-based chemotherapy
drug delivery … The large-scale production of mesenchymal stromal cells (MSCs) loaded …

Mesenchymal stem cells as therapeutic delivery vehicles targeting tumor stroma

N Serakinci, R Christensen, U Fahrioglu… - Cancer Biotherapy …, 2011 - liebertpub.com
… to home to tumor site and serve as a delivery platform for chemotherapeutic agents. … stromal
cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy. Stem Cells

Mesenchymal stem/stromal cells as next-generation drug delivery vehicles for cancer therapeutics

Y Takayama, K Kusamori… - … opinion on drug delivery, 2021 - Taylor & Francis
… types with tumor-homing ability can be developed as drug delivery vehicles … -homing cells,
mesenchymal stem/stromal cells (MSCs) are the most attractive candidates for drug delivery

Challenges and advances in clinical applications of mesenchymal stromal cells

T Zhou, Z Yuan, J Weng, D Pei, X Du, C He… - Journal of hematology & …, 2021 - Springer
… Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been
intensely investigated … (4) Utilize the MSCs secretome as a drug delivery platform for treatment …

Therapeutic drugs and drug delivery systems targeting stromal cells for cancer therapy: a review

Z Li, Z Zheng, C Li, Z Li, J Wu, B Zhang - Journal of drug targeting, 2020 - Taylor & Francis
stromal cells, besides, the current status on the targeting drugs as well as the drug delivery
… tumour stromal cells, the antitumor drugs targeting stromal cells and the DDS are discussed. …