… Here we report the high resolution structures of human β-defensin-1 (hBD1) in two …
understanding the structural basis of antimicrobial and chemotactic properties of human β-defensins. …

… structural basis for the capacity of β-defensins and CCL20/MIP3α to interact with the same
receptor. This region flanks the first cysteine. Work by41 with HBD3 revealed that the cysteine …

… structural similarity, human β-defensin 3 (HBD3) kills Staphylococcus aureus with a 4- to 8-fold
higher efficiency than human β-defensin … Among them are the defensins, a family of small …

… In addition to its antimicrobial activity, defensins present other activities such as … We
have solved the structure of the hBD6 by NMR spectroscopy that contains a conserved β-defensin …

… resolution x-ray structures of human β-defensin-2 (… defensins, an additional α-helical
region makes this protein topologically distinct from the mammalian α- and β-defensin structures …

… structural study of this protein is the first step towards establishing a structure–activity
relationship and forms the basis … of the three-dimensional structure of defensin A derived from an …

… -bulge in the second strand occurs at Gly28, a position conserved in the entire defensin … to
solution structures of α-defensins or to the β-defensin BNBD-12. This novel structural element …

… To rationalize these observed structural differences across the family, we believe it is …
structure on the biological activity of β-defensins. We recently described a murine β-defensin gene …

… The defensins from across the animal, plant and fungal … , the cis- and trans-defensins, each
of which has an independent … of 2714 defensin and defensin-like sequences and structures, …

… Both the α- and β-defensin gene families evolved from an ancestral β-defensin gene and
distinct clusters of both families are found adjacent on the chromosomal maps of all mammals …