… made in the development of PDKs inhibitors. Since for the latter… responsible for the PDKs
inhibition were recognized [4], we … a single structure, to design the novel PDK inhibitors. Among …

… pharmacological evaluation of potent PDK inhibitors targeting the PDK/PDC axis. We
successfully identified 6 compounds from a small molecule library through a structure-based virtual …

… As reported in Table 1, the structural manipulations on the pyridonyl nucleus seem to be
the most effective ones, especially when coupled with the R-PG linker. Among this series, …

… requiring major, time-consuming structural manipulation to remove unattractive features, …
, and these cores required major structural manipulations to remove unattractive features of …

… and of PDK-1, 115-118 the use of novel approaches to inhibiting specific isozymes, 119
and the identification of protein kinase C in lower eukaryotes, where genetic manipulation is …

… of PDK regulation by metabolites include its inhibition by the … allowed determination of the
primary structure of PDK (41). … to nutritional and endocrine manipulations that increase lipid …

… structure-based optimization of celecoxib to develop PDK-1 inhibitors with greater potency
in enzyme inhibition … All of the molecular modeling calculations and manipulations were …

… antitumor activity of this NOS inhibitor by supplementing its molecular structure with a PDK-…
After 24 h from the beginning of the manipulations, all animals were euthanized. The liver …

… in controlling meiotic spindle structure and metabolic activity, … (PDKs) are important inhibitors
of PDH activity in numerous … oocytes, we genetically manipulated PDK activity and then …

… Here we summarize the structure–function relationships delineating the activation process
of class I PI3Ks involving various domains of adapter subunits, Ras, and interacting proteins. …