… The purpose of this article is to review the structural basis, anti-cancer activities, and … on
the optimizing strategies to improve the anticancer activities, such as structural modifications, …

… Despite its acceptance as a design tool, however, structural optimization seems yet to gain …
on structural optimization with emphasis on their relation to mechanical product development, …

… elucidated solution structures of our products were obtained by 2D NMR spectroscopy,
then, on the basis of QM approach their energies and conformations were optimized and were …

… This also demonstrated the feasibility of the FBDD method of structural optimization. … A, and
increasing the structural diversity of type II inhibitors, we here reported the optimization of (−)-…

… by the structure or pharmacophore of natural products. Therefore, natural products often serve
as lead … and are subjected to structural optimization to generate clinically useful structures. …

… optimization of a product’s first shape mode. This methodology helps to optimize the overall
dimensions of a mechanical product. … optimization leads to the design concept of a product …

… Herein, we present initial chemical optimization and structure-activity relationship (SAR)
data … Nine novel structures were identified that increased the efficacy of a panel of antibiotics, …

… natural products provide excellent leads for drug discovery, ultimately producing viable
drugs, is a widely accepted view. Natural products embody inherent structural … natural product …

… THE concept of optimization is intrinsically tied to natural phenomena as well as to the …
Shay," recorded man's desire to produce a uniformly strong, durable product.In this case it was the …

… marine natural products: … natural products for the control of malaria. Manzamines are a
specific example of how a unique group of highly active marine natural products can be optimized …