… structures. In particular, their work on examining the stereospecific interactions of human
carboxylesterase … These structure-based studies are vital to increasing our understanding of CE …

… human, two major CEs including human carboxylesterase 1 (hCE1) and human carboxylesterase
… These two human CE isoforms (hCE1 and hCE2) share 47% amino acid sequence …

… for hiCE compared with the human liver CE hCE1, and none was an inhibitor of human
acetylcholinesterase or butyrylcholinesterase. Quantitative structure-activity relationship (QSAR) …

Human carboxylesterase 1 (hCE1), one of the most … their inhibitory effects against human
carboxylesterases (hCEs) were … were assayed and the structure-activity relationships of tested …

… human, most CEs identified to date belong to two isoforms, human carboxylesterase 1 (hCE1)
and human … acid derivatives against two major human carboxylesterases. The inhibitory …

… We sought to clarify the confusing gene structure of human CES1A. … Human carboxylesterases
(CES) are members of the serine esterase superfamily and are responsible for hydrolysis …

Background Human carboxylesterases (hCES) are key serine hydrolases responsible for
the hydrolysis of a wide range of endogenous and xenobiotic esters. Although it has been …

… of human carboxylesterases in drug metabolism: Have we overlooked their importance?
Pharmacotherapy, 2013, 33(2), 210-222. [10] Ross, MK; Crow, JA Human carboxylesterases …

… substrate for mammalian serum carboxylesterase (7), and has been used to monitor
carboxylesterase activity in the affinity purification of mammalian liver carboxylesterases (8). In a …

… demonstrated activity consistently similar to that of humans. A human liver carboxylesterase
… of similarity with the sequence of liver carboxylesterase from rat and rabbit (Riddles et al., …