… receptors. In addition, and taking into account that sequence determines structure and that
both tachykinins and their receptors … evolution of tachykinin and tachykinin receptor sequences…

… requirements for further potent and selective tachykinin receptor ligands have never been …
a structure–activity relationship (SAR) of naturally occurring vertebrate/invertebrate tachykinin …

… structureactivity relationships of these peptides will not be reported here. The tachykinin
receptors … actions do not involve activation of NK" N~, and NK3 receptors (Cascieri et aI., 1992). …

… The aim of this study was to assess the activities … tachykinin NK 2 receptor in a natural
system such as human colon circular muscle. In the gastrointestinal tract, selective NK 2 receptor …

… NKA 1 , one of five mammalian tachykinins, is the endogenous ligand for the tachykinin
NK 2 receptor. In peripheral tissues, such as the smooth muscle of the gastrointestinal, …

… Abstract: We report herein the synthesis and structure-activity relationships of a series of
novel oxazolidine analogues with regards to NK~ and NK 2 tachykinin receptor binding affinity. …

… (a) NK1 receptor preferring tachykinins. The majority of the natural TKs are NK1 receptor
preferring peptides and contain a neutral (Asn, Gln, Ala, Gly) or basic residue (Lys, His) at …

… for activity toward allthree typical tachykinin receptors (NK-1, NK-2, and NK-3), whereas
other positions can apparently tolerate substitution with Ala without a major loss of activity(…

… In the 1980’s, molecular characterization of TK genes and TK receptors as well as various
structure/activity relationship and pharmacologic studies of TK peptides allowed researchers …

… The tachykinin NK 3 receptor (NK 3 R) is a novel drug target for … receptor are available, we
have initiated this study to gain a better understanding of the structure–activity relationships of …