… described coincidently that there are two receptor subtypes … tachykinin peptides following
the proposal of Lee et al (5), … for subclassification of mammalian tachykinin peptides (6,7), we …

… receptors, tachykinins … on structure–activity relationships established the importance of the
specific chemical characteristics of neurokinins that are necessary to trigger their receptors [4]. …

… from stress-related disorders, several diverse tachykinin receptor antagonists, as well as …
by tachykinincontaining fibres and tachykinin receptors, mainly NK1 and NK3 receptors, are …

… The three human tachykinin receptors have been cloned and expressed (Buell et al., 1992;
… The endogenous tachykinin ligands interact with all tachykinin receptors, although there is a …

… -2 receptor agonists 12 (GR64349) and 31 are described, together with structure-activity
relationships for … 3.7 nM at NK-2 receptors in the rat colon; selectivity >1000- and >300-fold with …

… respective NK receptors. Structure-activity relationship studies of tachykinin systems allowed
… antagonists with selectivity to each of the three NK receptor types. There are some common …

… tachykinin and non-tachykinin receptors and ion channels (Table 3). GR205171 potently
inhibited [3H]SP binding to the NK 1 receptor … than at the human NK t receptor (pK i 10.6 _+ 0.22…

… In particular, she is involved in the structure-activity relationships of tachykinins and
neuropeptides. Carlo Albert0 Maggi obtained his degree in Medicine at the University of Florence, …

… and the development of a structure−activity relationship between the ligands and their
receptors may be obtained. The earliest known members of the tachykinin family are those that …

… in vitro activity of the compounds synthesized in this paper, we employed a receptor binding
… We also assessed the in vivo activity to inhibit airway edema inducedby SP in guinea pigs …