… human, two major CEs including human carboxylesterase 1 (hCE1) and human carboxylesterase
… These two human CE isoforms (hCE1 and hCE2) share 47% amino acid sequence …

… In our search for natural human carboxylesterase 2 (hCE 2) inhibitors from natural products,
we investigated inhibitory effects and mechanisms of flavonoids (1–16) against hCE 2. The …

… relatively bulky phosphorylated flavonoids can only enter into the larger active site pocket
of CEase and CE. Gosh and coworkers have reported that human carboxylesterase isoform 1 (…

… Our results highlighted that extracts including flavonoid derivatives show potent CE … inhibitory
effect could be attributed to the flavonoids alone, although Pistacia lentiscus and Teucrium …

Mammalian carboxylesterases (CEs) are important serine hydrolases catalyzing the hydrolysis
of ester- or amide-containing compounds into the corresponding alcohols and carboxylic …

… more than fifty flavonoids against human carboxylesterases are assayed. … flavonoids against
hCE1 and to find potential specific hCE1 inhibitors. To this end, fifty-eight natural flavonoids …

Aims Carboxylesterase (CES) plays an essential role in the hydrolysis of ester prodrugs.
Our study explored the inhibitions of Radix Scutellariae flavones, including baicalein (B), …

… phos phoryl and dibutylphosphoryl flavonoid derivatives. … on inhibitor activity of flavonoid
derivatives towards three … and selectivity of diisopropylphosphoryl flavonoid derivatives (3…

… The most potent inhibitors of carboxylesterase found to date are synthetic … flavonoids extracts
from plants used in Arab folk medicine on porcine liver and rat intestinal carboxylesterase […

… Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in
the small intestine, has been validated as a key therapeutic target to ameliorate the intestinal …