… AF, we undertook a genome-wide association study (GWAS) of 6,337 AF individuals and …
genome and identified seven risk loci, including two novel loci. One novel locus (lead single-…

… studies in model systems such as those included in this study. This work suggests that
interaction studies between genetic risk loci … personalized risk from genetic association studies. …

… studies have uncovered genomic loci that underlie an increased risk for atrial fibrillation,
the major cardiac arrhythmia … The most significant locus is located in a gene desert at 4q25, …

… Using a 2-stage design, adding 10,898 new cases and 76,535 controls to the 60,801/130,681
controls/cases previously studied by the CARDIoGRAMplusC4D consortium, we identified …

… associated with atrial fibrillation in a candidate gene association study, although not in our
present analysis 14 . The top SNP at the CAV1 locus identified in the current study, rs3807989…

… study sought to examine the 4q25 AF risk locus identified by genome-wide association studies.8,
… The 4q25 locus exists in a nonprotein coding (intronic) chromosomal segment, and the …

… (GWAS) have been published reporting chromosomal loci in association with AF, but these
studies have not yet succeeded to explain the heritable fraction of the disease. With this …

… We sought to determine whether additional AF susceptibility signals exist within loci
previously identified in genome-wide association studies of AF among participants of European …

… Three distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 have been associated
with atrial fibrillation (AF) in genome-wide association studies (GWAS). Five additional loci …

… this locus and AF remains unclear, these studies have … risk loci. In the following section, we
will discuss in detail the evidence relating to the 4q25 locus and AF followed by a discussion …