Clinical pharmacokinetics of erlotinib in patients with solid tumors and exposure‐safety relationship in patients with non–small cell lung cancer

JF Lu, SM Eppler, J Wolf, M Hamilton… - Clinical …, 2006 - Wiley Online Library
… The primary objective of this study was to characterize the pharmacokinetics of erlotinib in
a large number of patients with solid tumors and identify covariates that have an impact on its …

[HTML][HTML] … (JO22903) of first-line erlotinib in Japanese patients with epidermal growth factor receptor (EGFR) mutation-positive advanced non-small-cell lung cancer  …

K Goto, M Nishio, N Yamamoto, K Chikamori, T Hida… - Lung Cancer, 2013 - Elsevier
… The safety profile of erlotinib in this study was as expected… study received treatment with
erlotinib for a longer duration than patients treated in the second- and third-line Japanese studies

[HTML][HTML] Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non–small-cell lung cancer

EB Haura, T Tanvetyanon, A Chiappori… - Journal of Clinical …, 2010 - ncbi.nlm.nih.gov
… of elevated Src activity in human lung cancers, we conducted a phase I trial of combined
erlotinib and dasatinib in patients with advanced non–small-cell lung cancer (NSCLC). The …

Risk of interstitial lung disease with gefitinib and erlotinib in advanced non-small cell lung cancer: a systematic review and meta-analysis of clinical trials

L Shi, J Tang, L Tong, Z Liu - Lung Cancer, 2014 - Elsevier
… non-small cell lung cancer (NSCLC). Based on the results of two multicenter phase II studies
[1… Our search yielded a total of 496 potentially relevant studies with gefitinib or erlotinib. The …

[HTML][HTML] Erlotinib versus gefitinib for control of leptomeningeal carcinomatosis in non–small-cell lung cancer

E Lee, B Keam, DW Kim, TM Kim, SH Lee… - Journal of Thoracic …, 2013 - Elsevier
… The purpose of this study was to assess efficacies of erlotinib and gefitinib in the management
of LMC from NSCLC by comparing the cytologic negative conversion rates of the CSF in …

Erlotinib in non-small cell lung cancer: a review

FH Blackhall, S Rehman, N Thatcher - Expert opinion on …, 2005 - Taylor & Francis
… Recently, randomised, placebo-controlled, Phase III data for gefitinib from the ISEL (Iressa
Survival Evaluation in Lung cancer) study, that investigated treatment with gefitinib compared …

Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised …

MC Garassino, O Martelli, M Broggini, G Farina… - The lancet …, 2013 - thelancet.com
Erlotinib is registered for treatment of all patients with advanced non-small-cell lung cancer
(… Three studies have described activating mutations in advanced NSCLC that made tumours …

[HTML][HTML] Maintenance erlotinib versus erlotinib at disease progression in patients with advanced non-small-cell lung cancer who have not progressed following …

S Cicènas, SL Geater, P Petrov, Y Hotko, G Hooper… - Lung Cancer, 2016 - Elsevier
… The phase III IUNO trial assessed the benefit of maintenance erlotinib versus erlotinib at
progression in advanced/metastatic non-small-cell lung cancer (NSCLC) that had not …

Adjuvant erlotinib versus placebo in patients with stage IB-IIIA non–small-cell lung cancer (RADIANT): A randomized, double-blind, phase III trial

K Kelly, NK Altorki, WEE Eberhardt… - Journal of Clinical …, 2015 - escholarship.org
… non–small-cell lung cancer (NSCLC). We hypothesized that erlotinib would be efficacious in
… In conclusion, this study did not show a DFS benefit for erlotinib in patients with IHC- or FISH…

Erlotinib in cancer treatment

MA Bareschino, C Schettino, T Troiani, E Martinelli… - Annals of oncology, 2007 - Elsevier
… -cell lung cancer (NSCLC) is among the epithelial cancers that … This study showed that
erlotinib significantly prolonged survival … lung cancer symptoms, showed that patients receiving …