… novel synthetic adenosine derivatives for their agonist activity against the A 1 R, A 2A R,
and A 2B R. We explored subtype … cell assays have identified novel adenosine nucleosides …

… In conclusion, a series of novel non-alkyne mGlu5 receptor antagonists have been discovered.
Tetrazole derivatives 47 and 48 have a profile comparable with that of alkyne derivative …

… discovery of multiple novel scaffolds possessing diverse activities as mGluR5 allosteric
modulators. These novel … Furthermore, these novel compounds are active in vivo and show that …

… approach to discover novel D 3 ligands. Using this approach, we were able to discover 4 …
of 20 compounds selected for testing in the D 3 receptor binding assay. Testing of eight other …

… The virtual screening in this study did not explicitly target subtype selectivity, yielding hits
that bind equally well to both A2A and A1 adenosine receptor subtypes. Most hit compounds, …

… subtype for memory and attention mechanisms. Unfortunately, it has been difficult to develop
selective activators of M 1 and other individual mAChR subtypes, … have discovered a novel …

… characterization of a novel human CysLT receptor subtype that we have named the CysLT
2 receptor and report the tissue distribution of its expression. The receptor shows a selective …

… 4 receptor selectivity. The preference order of the different MC receptor subtypes for the novel
[… as they bind the MC 4 receptor with high and the MC 1 receptor with low relative affinities. …

… degradation of active angiotensin peptides and three receptor subtypes (AT 1 , AT 2 and AT
… recently discovered receptor subtype, AT 4 . Descriptions of classic and novel physiologies …

… encoded by the rat gene rg.20, and it has been suggested that this represents a novel
receptor subtype - the CQDadrenoeepto?‘. On the other hand, rg2U shares greater than 90% se…