… (LPS) stimulation, macrophages shift from producing ATP by oxidative … succinate levels.
We show that increased mitochondrial oxidation of succinate via succinate dehydrogenase (SDH…

… Here, we show that itaconate modulates macrophage metabolism … succinate
dehydrogenase-mediated oxidation of succinate. Through this action, itaconate exerts anti-inflammatory …

… ) in macrophage functions remains understudied. Here, we provide evidence that the succinate
dehydrogenase (… a role in controlling effector responses in macrophages. We find that the …

… is known to accumulate in LPS- and LPS + IFN-γ-stimulated cells at least partially due to
succinate dehydrogenase (SDH) inhibition [15], we simulated this effect by pre-treating BMDMs …

… Both macrophages treated with LPS and tumors with succinate … inhibition of succinate
dehydrogenase (SDH), the enzyme responsible for the conversion of succinate to fumarate, or …

… activation in activated macrophages, contributing to inflammatory responses. … -inflammatory
activity. In this study, we investigated the effects of Tan-IIA on inflammation in macrophages …

… In this study, we asked whether the stabilization of HIF1α in M(LPS) macrophages alters
TCA cycle fluxes similarly to hypoxic cells. We show that LPS-activated macrophages exhibit a …

… TAM depletion-repletion experiments in a 4T1 mouse model additionally revealed that
anti-inflammatory macrophages promoted HIF-associated vascularization and expression of the …

… succinate serves to facilitate the execution of inflammatory … succinate dehydrogenase
inhibitor to cause succinate accumulation. Loss of itaconate production in activated macrophages …

… inflammation and diseases. This study aims to explore the energy metabolism of macrophages
under either inflammatory or anti-inflammatory … that inflammation in macrophages disrupts …