Preferential expression of matrix metalloproteinase9 in mouse skin after sulfur mustard exposure

MP Shakarjian, P Bhatt, MK Gordon… - Journal of Applied …, 2006 - Wiley Online Library
… In skin, MMP-2 (gelatinase A) and MMP9 (gelatinase B) are … expression of MMP-2 and -9
was studied in sulfur mustard (… and assayed for MMP-2 and -9 expression by gelatinase activity …

Cytokine, chemokine, and matrix metalloproteinase response after sulfur mustard injury to weanling pig skin

CLK Sabourin, MM Danne, KL Buxton… - … of biochemical and …, 2002 - Wiley Online Library
… increased MMP-9 mRNA levels were observed; however, MMP… where MMP-9 mRNA levels
were increased whereas MMP-2 … A temporal link between human MMP-9 enzymatic activity …

[PDF][PDF] Correlation between MMP-9 and MMP-9/TIMPs complex with pulmonary function in sulfur mustard exposed civilians: Sardasht-Iran cohort study

S Ghaffarpour, T Ghazanfari, SK Ardestani… - Archives of Iranian …, 2017 - journalaim.com
… problems in sulfur mustard injured group in SICS.… MMP-9 and MMP-9/TIMP complexes did
not have any correlation with spirometry findings, a significant elevation was shown in MMP9

Chemokines, MMP-9 and PMN elastase in spontaneous sputum of sulfur mustard exposed civilians: Sardasht-Iran Cohort Study

S Pourfarzam, R Yaraee, ZM Hassan… - International …, 2013 - Elsevier
… We measured sputum and serum MMP-9 levels but not MMP-9 activity which might be a
limitation in the analysis of the current study. It is likely that the MMP-9 activation influences the …

[HTML][HTML] Serum matrix metalloproteinase levels in patients exposed to sulfur mustard

M Shohrati, RH Hosseini, MA Esfandiari… - Iranian Red Crescent …, 2014 - ncbi.nlm.nih.gov
… exposed to sulfur mustard in comparison to the normal people (26). Our results showed
that serum MMP-8 increased in patients who were exposed to sulfur mustard in comparison to …

Inflammatory effects of inhaled sulfur mustard in rat lung

R Malaviya, VR Sunil, J Cervelli, DR Anderson… - Toxicology and applied …, 2010 - Elsevier
… Inhalation of sulfur mustard (SM), a bifunctional alkylating … (iNOS), and matrix
metalloproteinase-9 (MMP-9), each of which has … in alveolar regions, MMP-9 was prominent in …

Matrix metalloproteinase-9 expression and release from skin fibroblasts interacting with keratinocytes: Upregulation in response to sulphur mustard

C Ries, T Popp, V Egea, K Kehe, M Jochum - Toxicology, 2009 - Elsevier
… Two members of the MMP family, MMP-2 and MMP-9, are subclassified as gelatinases due
to their preferential ability to digest denatured collagens (gelatin) and collagen type IV, the …

Matrix Metalloproteinase 9 (MMP9) Inhibitor Prevents Mustard Induced Microvesication and Promotes Cutaneous Wound Healing

YC Chang, S Muhn, RA Hahn, MK Gordon… - The FASEB …, 2020 - Wiley Online Library
… Skin exposure to the chemical warfare agent, sulfur mustard (bis-2-chloroethylsulfide, SM), …
by overexpression of MMP9. Studies show MMP9 degrades basement membrane (BM) …

Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure

MP Shakarjian, DE Heck, JP Gray, PJ Sinko… - Toxicological …, 2010 - academic.oup.com
Sulfur mustard (SM), a chemical weapon first employed during World War I, targets the skin,
eyes, and lung. It remains a significant military and civilian threat. The characteristic …

The beneficial effects of doxycycline, an inhibitor of matrix metalloproteinases, on sulfur mustard-induced ocular pathologies depend on the injury stage

V Horwitz, S Dachir, M Cohen, H Gutman… - Current eye …, 2014 - Taylor & Francis
MMPs) activity, we evaluated the clinical and biochemical effects of topical treatment with
doxycycline, an MMP … time points for measurements of MMPs activity by zymography. Efficacy …