Sulfur mustard (SM) is highly toxic to the lung inducing both acute and chronic effects including
upper and lower obstructive disease, airway inflammation, and acute respiratory distress …

Sulfur mustard (SM) is a potent alkylating agent that targets several organs, especially lung
tissue. Although pathological effects of SM have been widely considered, molecular and …

… Chronic pulmonary problems include decreases in lung function, bronchitis with … , pulmonary
fibrosis, decreased total lung capacity, and increased incidences of lung cancer, pulmonary …

… The goal of the present study was to characterize pulmonary injury and inflammation in
response to inhaled SM in a rodent model. Elucidating specific inflammatory mediators and cell …

… to pulmonary injuries and complications caused by its inhalation. Profound inflammation,
hypercoagulation, and oxidative stress are the hallmarks that define SM-induced pulmonary …

… and DNA methyl transferase may be potential targets for epigenetic drug development,
and Trichostatine A may be one of candidate drugs for treating delayed pulmonary injury. …

… used for studying HD-induced pulmonary toxicity and potential countermeasures (currently, …
can be used to monitor pulmonary toxicity directly at the site of injury, the airways and alveoli…

… Exposure of humans and animals to vesicants, including sulfur mustard (SM) and nitrogen
mustard (NM), causes severe and debilitating damage to the respiratory tract. Both acute and …

… Alteplase (human recombinant tPA), our proposed MCM to treat victims in the acute phase
of pulmonary injury after SM, has several distinct advantages, as outlined here. Among these …

… Chronic obstructive pulmonary disease (COPD) is a late toxic pulmonary consequence
after SM exposure. The COPD observed in these patients is unique (described as …