… HFD leads to dysregulation of hepatic lipid metabolism in mice. We determined the effects …
To gain further insight into the long-term effects of TM6SF2 on hepatic cholesterol metabolism, …

… Thioesterase superfamily member 2 (Them2; synonym Acot13) is a broadly expressed …
reduced hepatic glucose production. To examine the role of Them2 in regulating hepatic lipid and …

… The relative contributions of various members of perilipin family in lipid … members of the
Cide family of lipid droplet proteins CideA, CideB, and CideC (also known as Fsp27), in lipid …

… To gain insights into the potential role of THEM2 in human hepatic lipid metabolism, we
analyzed liver samples from obese subjects with normal livers, simple steatosis, or NASH (…

… that protects against hepatic lipotoxicity resulting from the increased flux of fatty acids
during insulin resistance (IR).This hepatic lipid accumulation is the hallmark of NAFLD.NAFLD …

… superfamily member 2 (TM6SF2). Moreover, a significant, positive relationship was observed
between hepatic … secretion of TG-rich lipoproteins (TRLs) and hepatic lipid droplet content. …

… Recently, a variant (rs58542926) coding for a missense mutation (Glu167Lys) in the
transmembrane 6 superfamily member 2 (TM6SF2) gene was identified in the Dallas Heart Study …

… LXRs that belong to the nuclear receptor superfamily of ligand-activated transcription factors
and … In summary, hepatic lipid metabolism is a highly co-ordinated process, in which many …

… Liver X receptors (LXRs) are members of the superfamily of … other processes correlating
with lipid metabolism. LXRs can … ) is classically associated with lipid metabolic disorders and …

… factor superfamily members, IFNs and caspases; (b) lipid … /enhancer binding protein α and
hepatic mitogens. In conclusion, … vital for establishing normal hepatic energy homeostasis and …