… In the 1990s, an antioxidant enzyme—superoxide dismutase (SOD)—was introduced into
the market. Although the enzyme initially showed great promise in therapeutic applications, it …

… Manganese superoxide dismutase (MnSOD) is an enzyme present in … -related diseases.
In this paper, we will discuss the role of MnSOD in various inflammation-associated diseases …

… superoxide dismutase, glutathione peroxidase, and catalase working together in human cells
… process as well as in a number of human disease states, including cancer, ischemia, and …

… Similar to the other isoforms of SOD, no mutation leading to the complete catalytic
inactivation of MnSOD has been observed in any human disease to date. Active mutant forms of …

… The balance between ROS production and antioxidant capacity is delicate, and disruption
of it contributes to the pathophysiology of numerous diseases. In 1969, the first antioxidant …

… regarding superoxide dismutase … human kidney allograft rejection and human pancreatic
ductal adenocarcinoma [38] , tyrosine nitration being identified in more than 50 human diseases…

The clinical trials performed with bovine superoxide dismutase (SOD) are reviewed. SOD,
applied intraarticularly at a dosage of 2–16 mg, proved to be effective in osteoarthritis of the …

… Copper-zinc superoxide dismutase has been used, with success, as a drug in the … of a new
potential anticolitic agent—the lecithinized superoxide dismutase (PC-SOD).14, 15 Research …

… superoxide dismutase in human plasma and tissue. Biochem J 1993;294:853-857. [21]
Adachi T, Marklund SL. Interactions between human extracellular superoxide dismutase C and …

… Much of our knowledge on clinical use of SOD in humans is derived from its topic … intravenous
treatment in ischaemic disease. Native Cu-Zn superoxide dismutase, purified from bovine …